2odd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:17, 28 December 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2odd.png|left|200px]]
 
-
<!--
+
==Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor==
-
The line below this paragraph, containing "STRUCTURE_2odd", creates the "Structure Box" on the page.
+
<StructureSection load='2odd' size='340' side='right'caption='[[2odd]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2odd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ODD FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_2odd| PDB=2odd | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2odd OCA], [https://pdbe.org/2odd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2odd RCSB], [https://www.ebi.ac.uk/pdbsum/2odd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2odd ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/2odd_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2odd ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
AML1/ETO results from the t(8;21) associated with 12%-15% of acute myeloid leukemia. The AML1/ETO MYND domain mediates interactions with the corepressors SMRT and N-CoR and contributes to AML1/ETO's ability to repress proliferation and differentiation of primary bone marrow cells as well as to enhance their self renewal in vitro. We solved the solution structure of the MYND domain and show it to be structurally homologous to the PHD and RING finger families of proteins. We also determined the solution structure of an MYND-SMRT peptide complex. We demonstrated that a single amino acid substitution that disrupts the interaction between the MYND domain and the SMRT peptide attenuated AML1/ETO's effects on proliferation, differentiation, and gene expression.
-
===Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor===
+
Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.,Liu Y, Chen W, Gaudet J, Cheney MD, Roudaia L, Cierpicki T, Klet RC, Hartman K, Laue TM, Speck NA, Bushweller JH Cancer Cell. 2007 Jun;11(6):483-97. PMID:17560331<ref>PMID:17560331</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_17560331}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2odd" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 17560331 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_17560331}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2ODD is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODD OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:17560331</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Bushweller, J H.]]
+
[[Category: Large Structures]]
-
[[Category: Chen, W.]]
+
[[Category: Bushweller JH]]
-
[[Category: Cheney, M D.]]
+
[[Category: Chen W]]
-
[[Category: Cierpicki, T.]]
+
[[Category: Cheney MD]]
-
[[Category: Gaudet, J.]]
+
[[Category: Cierpicki T]]
-
[[Category: Hartman, K.]]
+
[[Category: Gaudet J]]
-
[[Category: Klet, R C.]]
+
[[Category: Hartman K]]
-
[[Category: Laue, T M.]]
+
[[Category: Klet RC]]
-
[[Category: Liu, Y Z.]]
+
[[Category: Laue TM]]
-
[[Category: Roudaia, L.]]
+
[[Category: Liu YZ]]
-
[[Category: Speck, N A.]]
+
[[Category: Roudaia L]]
-
[[Category: Cross-braced topology]]
+
[[Category: Speck NA]]
-
[[Category: Mynd zinc finger]]
+
-
[[Category: Poly-proline]]
+
-
[[Category: Proline-tryptophan interaction]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:39:04 2009''
+

Current revision

Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor

PDB ID 2odd

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2odd"
Personal tools