3b6z

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{{Seed}}
 
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[[Image:3b6z.png|left|200px]]
 
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==Lovastatin polyketide enoyl reductase (LovC) complexed with 2'-phosphoadenosyl isomer of crotonoyl-CoA==
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The line below this paragraph, containing "STRUCTURE_3b6z", creates the "Structure Box" on the page.
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<StructureSection load='3b6z' size='340' side='right'caption='[[3b6z]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3b6z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_terreus Aspergillus terreus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B6Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO7:S-{(9R,13R,15S)-17-[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]-9,13,15-trihydroxy-10,10-dimethyl-13,15-dioxido-4,8-dioxo-12,14,16-trioxa-3,7-diaza-13,15-diphosphaheptadec-1-yl}(2E)-but-2-enethioate'>CO7</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_3b6z| PDB=3b6z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b6z OCA], [https://pdbe.org/3b6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b6z RCSB], [https://www.ebi.ac.uk/pdbsum/3b6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b6z ProSAT]</span></td></tr>
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</table>
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===Lovastatin polyketide enoyl reductase (LovC) complexed with 2'-phosphoadenosyl isomer of crotonoyl-CoA===
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== Function ==
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[https://www.uniprot.org/uniprot/LOVC_ASPTE LOVC_ASPTE] Catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the LovB-mediated biosynthesis of the lovastatin nonaketide chain.<ref>PMID:10334994</ref> <ref>PMID:19900898</ref> <ref>PMID:22733743</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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3B6Z is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Aspergillus_terreus Aspergillus terreus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B6Z OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/3b6z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b6z ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Aspergillus terreus]]
[[Category: Aspergillus terreus]]
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[[Category: Ames, B D.]]
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[[Category: Large Structures]]
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[[Category: Ma, S M.]]
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[[Category: Ames BD]]
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[[Category: Smith, P T.]]
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[[Category: Ma SM]]
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[[Category: Tang, Y.]]
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[[Category: Smith PT]]
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[[Category: Tsai, S C.]]
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[[Category: Tang Y]]
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[[Category: Vederas, J C.]]
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[[Category: Tsai S-C]]
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[[Category: Wong, E W.]]
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[[Category: Vederas JC]]
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[[Category: Xie, X.]]
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[[Category: Wong EW]]
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[[Category: Medium-chain reductase]]
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[[Category: Xie X]]
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[[Category: Nadp-binding]]
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[[Category: Oxidoreductase]]
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[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:58:38 2009''
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Current revision

Lovastatin polyketide enoyl reductase (LovC) complexed with 2'-phosphoadenosyl isomer of crotonoyl-CoA

PDB ID 3b6z

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