3bpj

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{{Seed}}
 
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[[Image:3bpj.png|left|200px]]
 
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==Crystal structure of human translation initiation factor 3, subunit 1 alpha==
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The line below this paragraph, containing "STRUCTURE_3bpj", creates the "Structure Box" on the page.
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<StructureSection load='3bpj' size='340' side='right'caption='[[3bpj]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bpj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BPJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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{{STRUCTURE_3bpj| PDB=3bpj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bpj OCA], [https://pdbe.org/3bpj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bpj RCSB], [https://www.ebi.ac.uk/pdbsum/3bpj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bpj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EIF3J_HUMAN EIF3J_HUMAN] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.[HAMAP-Rule:MF_03009]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/3bpj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bpj ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human translation initiation factor 3, subunit 1 alpha===
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3BPJ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BPJ OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M.]]
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[[Category: Bochkarev A]]
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[[Category: Hong, B.]]
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[[Category: Edwards AM]]
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[[Category: MacKenzie, F.]]
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[[Category: Hong B]]
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[[Category: Nedyalkova, L.]]
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[[Category: MacKenzie F]]
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[[Category: Park, H.]]
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[[Category: Nedyalkova L]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Park H]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Eif3s1]]
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[[Category: Initiation factor]]
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[[Category: Limited proteolysis]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Protein biosynthesis]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Translation initiation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:00:48 2009''
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Current revision

Crystal structure of human translation initiation factor 3, subunit 1 alpha

PDB ID 3bpj

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OCA

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