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1tpg

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{{Seed}}
 
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[[Image:1tpg.png|left|200px]]
 
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==F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE)==
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The line below this paragraph, containing "STRUCTURE_1tpg", creates the "Structure Box" on the page.
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<StructureSection load='1tpg' size='340' side='right'caption='[[1tpg]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tpg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TPG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tpg OCA], [https://pdbe.org/1tpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tpg RCSB], [https://www.ebi.ac.uk/pdbsum/1tpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tpg ProSAT]</span></td></tr>
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{{STRUCTURE_1tpg| PDB=1tpg | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN] Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.
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== Function ==
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[https://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN] Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tp/1tpg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tpg ConSurf].
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<div style="clear:both"></div>
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===F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE)===
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==See Also==
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*[[Plasminogen activator|Plasminogen activator]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_7582899}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7582899 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7582899}}
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==About this Structure==
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1TPG is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPG OCA].
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==Reference==
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<ref group="xtra">PMID:7582899</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: T-plasminogen activator]]
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[[Category: Large Structures]]
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[[Category: Campbell, I D.]]
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[[Category: Campbell ID]]
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[[Category: Downing, A K.]]
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[[Category: Downing AK]]
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[[Category: Driscoll, P C.]]
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[[Category: Driscoll PC]]
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[[Category: Dudgeon, T J.]]
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[[Category: Dudgeon TJ]]
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[[Category: Smith, B O.]]
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[[Category: Smith BO]]
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[[Category: Plasminogen activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:08:31 2009''
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Current revision

F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE)

PDB ID 1tpg

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