2pla

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{{Seed}}
 
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[[Image:2pla.png|left|200px]]
 
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==Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein==
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The line below this paragraph, containing "STRUCTURE_2pla", creates the "Structure Box" on the page.
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<StructureSection load='2pla' size='340' side='right'caption='[[2pla]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2pla]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PLA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_2pla| PDB=2pla | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pla OCA], [https://pdbe.org/2pla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pla RCSB], [https://www.ebi.ac.uk/pdbsum/2pla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pla ProSAT]</span></td></tr>
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</table>
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===Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein===
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== Disease ==
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[https://www.uniprot.org/uniprot/GPD1L_HUMAN GPD1L_HUMAN] Brugada syndrome. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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== Function ==
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==About this Structure==
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[https://www.uniprot.org/uniprot/GPD1L_HUMAN GPD1L_HUMAN] Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.<ref>PMID:19666841</ref> <ref>PMID:19745168</ref>
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2PLA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLA OCA].
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/2pla_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pla ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bunkoczi, G.]]
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[[Category: Arrowsmith CH]]
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[[Category: Delft, F von.]]
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[[Category: Bunkoczi G]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Hozjan, V.]]
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[[Category: Hozjan V]]
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[[Category: Kavanagh, K.]]
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[[Category: Kavanagh K]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Papagrigoriou E]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike ACW]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Smee C]]
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[[Category: Smee, C.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Ugochukwu E]]
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[[Category: Ugochukwu, E.]]
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[[Category: Umeano C]]
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[[Category: Umeano, C.]]
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[[Category: Uppenberg J]]
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[[Category: Uppenberg, J.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Dehydrogenase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:23:19 2009''
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Current revision

Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein

PDB ID 2pla

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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