2acg

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(New page: 200px<br /><applet load="2acg" size="450" color="white" frame="true" align="right" spinBox="true" caption="2acg, resolution 2.5&Aring;" /> '''ACANTHAMOEBA CASTELLA...)
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[[Image:2acg.gif|left|200px]]<br /><applet load="2acg" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2acg, resolution 2.5&Aring;" />
 
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'''ACANTHAMOEBA CASTELLANII PROFILIN II'''<br />
 
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==Overview==
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==ACANTHAMOEBA CASTELLANII PROFILIN II==
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We determined the structures of Acanthamoeba profilin I and profilin II by, x-ray crystallography at resolutions of 2.0 and 2.8 A, respectively. The, polypeptide folds and the actin-binding surfaces of the amoeba profilins, are very similar to those of bovine and human profilins. The electrostatic, potential surfaces of the two Acanthamoeba isoforms differ. Two areas of, high positive potential on the surface of profilin II are candidate, binding sites for phosphatidylinositol phosphates. The proximity of these, sites to the actin binding site provides an explanation for the, competition between actin and lipids for binding profilin.
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<StructureSection load='2acg' size='340' side='right'caption='[[2acg]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2acg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ACG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2acg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2acg OCA], [https://pdbe.org/2acg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2acg RCSB], [https://www.ebi.ac.uk/pdbsum/2acg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2acg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PROF2_ACACA PROF2_ACACA] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ac/2acg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2acg ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2ACG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2ACG OCA].
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*[[Profilin 3D Structures|Profilin 3D Structures]]
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__TOC__
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==Reference==
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</StructureSection>
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X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates., Fedorov AA, Magnus KA, Graupe MH, Lattman EE, Pollard TD, Almo SC, Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8636-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8078936 8078936]
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[[Category: Acanthamoeba castellanii]]
[[Category: Acanthamoeba castellanii]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Almo, S.C.]]
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[[Category: Almo SC]]
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[[Category: Fedorov, A.A.]]
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[[Category: Fedorov AA]]
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[[Category: Graupe, M.H.]]
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[[Category: Graupe MH]]
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[[Category: Lattman, E.E.]]
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[[Category: Lattman EE]]
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[[Category: Magnus, K.A.]]
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[[Category: Magnus KA]]
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[[Category: Pollard, T.D.]]
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[[Category: Pollard TD]]
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[[Category: actin-binding protein]]
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[[Category: profilin]]
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[[Category: protein binding]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 08:02:54 2007''
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Current revision

ACANTHAMOEBA CASTELLANII PROFILIN II

PDB ID 2acg

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