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2he3

From Proteopedia

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{{Seed}}
 
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[[Image:2he3.png|left|200px]]
 
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==Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (GPX2)==
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The line below this paragraph, containing "STRUCTURE_2he3", creates the "Structure Box" on the page.
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<StructureSection load='2he3' size='340' side='right'caption='[[2he3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2he3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HE3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_2he3| PDB=2he3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2he3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2he3 OCA], [https://pdbe.org/2he3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2he3 RCSB], [https://www.ebi.ac.uk/pdbsum/2he3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2he3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GPX2_HUMAN GPX2_HUMAN] Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2he3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2he3 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (GPX2)===
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==See Also==
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*[[Glutathione peroxidase|Glutathione peroxidase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2HE3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE3 OCA].
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[[Category: Glutathione peroxidase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Delft, F Von.]]
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[[Category: Arrowsmith C]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Gileadi, O.]]
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[[Category: Gileadi O]]
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[[Category: Johansson, C.]]
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[[Category: Johansson C]]
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[[Category: Kavanagh, K L.]]
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[[Category: Kavanagh KL]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: Rojkova, A.]]
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[[Category: Rojkova A]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Gastrointestinal glutathione peroxidase 2]]
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[[Category: Gprp]]
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[[Category: Gshpx-gi]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Thioredoxin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:45:31 2009''
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Current revision

Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (GPX2)

PDB ID 2he3

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