1jnz

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{{Seed}}
 
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[[Image:1jnz.png|left|200px]]
 
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==Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6 resolution==
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The line below this paragraph, containing "STRUCTURE_1jnz", creates the "Structure Box" on the page.
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<StructureSection load='1jnz' size='340' side='right'caption='[[1jnz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jnz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JNZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene></td></tr>
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{{STRUCTURE_1jnz| PDB=1jnz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnz OCA], [https://pdbe.org/1jnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jnz RCSB], [https://www.ebi.ac.uk/pdbsum/1jnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jnz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O28603_ARCFU O28603_ARCFU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jnz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jnz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The iron-sulfur flavoenzyme adenylylsulfate (adenosine 5'-phosphosulfate, APS) reductase catalyzes reversibly the reduction of APS to sulfite and AMP. The structures of APS reductase from the hyperthermophilic Archaeoglobus fulgidus in the two-electron reduced state and with sulfite bound to FAD are reported at 1.6- and 2.5- resolution, respectively. The FAD-sulfite adduct was detected after soaking the crystals with APS. This finding and the architecture of the active site strongly suggest that catalysis involves a nucleophilic attack of the N5 atom of reduced FAD on the sulfur atom of APS. In view of the high degree of similarity between APS reductase and fumarate reductase especially with regard to the FAD-binding alpha-subunit, it is proposed that both subunits originate from a common ancestor resembling archaeal APS reductase. The two electrons required for APS reduction are transferred via two [4Fe-4S] clusters from the surface of the protein to FAD. The exceptionally large difference in reduction potential of these clusters (-60 and -500 mV) can be explained by interactions of the clusters with the protein matrix.
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===Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6 resolution===
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Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6-A resolution.,Fritz G, Roth A, Schiffer A, Buchert T, Bourenkov G, Bartunik HD, Huber H, Stetter KO, Kroneck PM, Ermler U Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1836-41. Epub 2002 Feb 12. PMID:11842205<ref>PMID:11842205</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11842205}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1jnz" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11842205 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11842205}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Archaeoglobus fulgidus DSM 4304]]
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1JNZ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNZ OCA].
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[[Category: Large Structures]]
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[[Category: Bartunik HD]]
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==Reference==
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[[Category: Bourenkov G]]
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<ref group="xtra">PMID:11842205</ref><references group="xtra"/>
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[[Category: Buechert T]]
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[[Category: Adenylyl-sulfate reductase]]
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[[Category: Ermler U]]
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[[Category: Archaeoglobus fulgidus]]
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[[Category: Fritz G]]
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[[Category: Bartunik, H D.]]
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[[Category: Huber H]]
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[[Category: Bourenkov, G.]]
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[[Category: Kroneck PM]]
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[[Category: Buechert, T.]]
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[[Category: Roth A]]
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[[Category: Ermler, U.]]
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[[Category: Schiffer A]]
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[[Category: Fritz, G.]]
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[[Category: Stetter KO]]
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[[Category: Huber, H.]]
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[[Category: Kroneck, P M.]]
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[[Category: Roth, A.]]
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[[Category: Schiffer, A.]]
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[[Category: Stetter, K O.]]
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[[Category: Adenylylsulfate reductase]]
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[[Category: Catalysis]]
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[[Category: Crystal structure]]
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[[Category: Iron-sulfur flavoprotein]]
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[[Category: Sulfur metabolism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:06:56 2009''
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Current revision

Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6 resolution

PDB ID 1jnz

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