2jtu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:29, 27 January 2022) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2jtu.png|left|200px]]
 
-
<!--
+
==NMR structure of iota-RXIA(38)==
-
The line below this paragraph, containing "STRUCTURE_2jtu", creates the "Structure Box" on the page.
+
<StructureSection load='2jtu' size='340' side='right'caption='[[2jtu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2jtu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JTU FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtu OCA], [https://pdbe.org/2jtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jtu RCSB], [https://www.ebi.ac.uk/pdbsum/2jtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtu ProSAT]</span></td></tr>
-
{{STRUCTURE_2jtu| PDB=2jtu | SCENE= }}
+
</table>
-
 
+
== Function ==
-
===NMR structure of iota-RXIA(38)===
+
[[https://www.uniprot.org/uniprot/CI1BA_CONRA CI1BA_CONRA]] Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin acts on Nav1.6/SCN8A > Nav1.2/SCN2A > Nav1.7/SCN9A sodium channels. Produces general excitatory symptoms upon intracorporeal injection and repetitive action potentials in the frog cutaneous pectoris muscle. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle.<ref>PMID:17696362</ref> <ref>PMID:18486102</ref>
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
==About this Structure==
+
Check<jmol>
-
2JTU is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTU OCA].
+
<jmolCheckbox>
-
[[Category: Norton, R.]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/2jtu_consurf.spt"</scriptWhenChecked>
-
[[Category: Wei, D.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jtu ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Norton, R]]
 +
[[Category: Wei, D]]
[[Category: Bromination]]
[[Category: Bromination]]
[[Category: D-amino acid]]
[[Category: D-amino acid]]
Line 24: Line 33:
[[Category: Secreted]]
[[Category: Secreted]]
[[Category: Toxin]]
[[Category: Toxin]]
- 
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:18:51 2009''
 

Current revision

NMR structure of iota-RXIA(38)

PDB ID 2jtu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jtu"
Personal tools