1zxf

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{{Seed}}
 
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[[Image:1zxf.png|left|200px]]
 
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==Solution structure of a self-sacrificing resistance protein, CalC from Micromonospora echinospora==
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The line below this paragraph, containing "STRUCTURE_1zxf", creates the "Structure Box" on the page.
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<StructureSection load='1zxf' size='340' side='right'caption='[[1zxf]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zxf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Micromonospora_echinospora Micromonospora echinospora]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZXF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxf OCA], [https://pdbe.org/1zxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zxf RCSB], [https://www.ebi.ac.uk/pdbsum/1zxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zxf ProSAT], [https://www.topsan.org/Proteins/CESG/1zxf TOPSAN]</span></td></tr>
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{{STRUCTURE_1zxf| PDB=1zxf | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8KNF0_MICEC Q8KNF0_MICEC]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/1zxf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zxf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The recent discovery of the first "self-sacrifice" mechanism for bacterial resistance to the enediyne antitumor antibiotics, where enediyne-induced proteolysis of the resistance protein CalC inactivates both the highly reactive metabolite and the resistance protein, revealed yet another ingenious bacterial mechanism for controlling reactive metabolites. As reported herein, the first 3D structures of CalC and CalC in complex with calicheamicin (CLM) divulge CalC to be a member of the steroidogenic acute regulatory protein (StAR)-related transfer (START) domain superfamily. In contrast to previous studies of proteins known to bind DNA-damaging natural products ( e.g ., bleomycins, mitomycins, and nine-membered chromoprotein enediynes), this is the first demonstrated involvement of a START domain fold. Consistent with the CalC self-sacrifice mechanism, CLM in complex with CalC is positioned for direct hydrogen abstraction from Gly113 to initiate the oxidative proteolysis-based resistance mechanism. These structural studies also illuminate, for the first time, a small DNA-binding region within CalC that may serve to localize CalC to the enediyne target (DNA). Given the role of START domains in nuclear/cytosolic transport and translocation, this structural study also may implicate START domains as post-endocytotic intracellular chaperones for enediyne-based therapeutics such as MyloTarg.
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===Solution structure of a self-sacrificing resistance protein, CalC from Micromonospora echinospora===
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Structural insight into the self-sacrifice mechanism of enediyne resistance.,Singh S, Hager MH, Zhang C, Griffith BR, Lee MS, Hallenga K, Markley JL, Thorson JS ACS Chem Biol. 2006 Aug 22;1(7):451-60. PMID:17168523<ref>PMID:17168523</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17168523}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1zxf" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17168523 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17168523}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1ZXF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Micromonospora_echinospora Micromonospora echinospora]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXF OCA].
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==Reference==
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<ref group="xtra">PMID:17168523</ref><references group="xtra"/>
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[[Category: Micromonospora echinospora]]
[[Category: Micromonospora echinospora]]
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
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[[Category: Griffith BR]]
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[[Category: Griffith, B R.]]
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[[Category: Hager MH]]
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[[Category: Hager, M H.]]
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[[Category: Hallenga K]]
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[[Category: Hallenga, K.]]
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[[Category: Lee MS]]
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[[Category: Lee, M S.]]
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[[Category: Markley JL]]
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[[Category: Markley, J L.]]
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[[Category: Singh S]]
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[[Category: Singh, S.]]
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[[Category: Thorson JS]]
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[[Category: Thorson, J S.]]
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[[Category: Zhang C]]
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[[Category: Zhang, C.]]
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[[Category: Center for eukaryotic structural genomic]]
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[[Category: Cesg]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Self-sacrificing resistance protein]]
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[[Category: Structural genomic]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:48:14 2009''
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Current revision

Solution structure of a self-sacrificing resistance protein, CalC from Micromonospora echinospora

PDB ID 1zxf

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OCA

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