1z83

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{{Seed}}
 
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[[Image:1z83.png|left|200px]]
 
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==Crystal structure of human AK1A in complex with AP5A==
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The line below this paragraph, containing "STRUCTURE_1z83", creates the "Structure Box" on the page.
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<StructureSection load='1z83' size='340' side='right'caption='[[1z83]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z83]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z83 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AP5:BIS(ADENOSINE)-5-PENTAPHOSPHATE'>AP5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1z83| PDB=1z83 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z83 OCA], [https://pdbe.org/1z83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z83 RCSB], [https://www.ebi.ac.uk/pdbsum/1z83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z83 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/KAD1_HUMAN KAD1_HUMAN] Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:[https://omim.org/entry/612631 612631].<ref>PMID:2542324</ref> <ref>PMID:9432020</ref> <ref>PMID:12649162</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/KAD1_HUMAN KAD1_HUMAN] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z83_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z83 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human AK1A in complex with AP5A===
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==See Also==
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*[[Adenylate kinase 3D structures|Adenylate kinase 3D structures]]
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== References ==
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==Disease==
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<references/>
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Known disease associated with this structure: Hemolytic anemia due to adenylate kinase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103000 103000]]
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__TOC__
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</StructureSection>
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==About this Structure==
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1Z83 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z83 OCA].
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[[Category: Adenylate kinase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bunkoczi, G.]]
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[[Category: Large Structures]]
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[[Category: Delft, F Von.]]
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[[Category: Bunkoczi G]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Filippakopoulos P]]
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[[Category: Jansson, A.]]
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[[Category: Jansson A]]
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[[Category: Knapp, S.]]
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[[Category: Knapp S]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Schreurs A]]
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[[Category: Schreurs, A.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Von Delft F]]
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[[Category: Adenylate kinase]]
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[[Category: Ap5a]]
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[[Category: Diadenosine pentaphosphate]]
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[[Category: Humna]]
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[[Category: Nucleotide kinase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:52:20 2009''
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Current revision

Crystal structure of human AK1A in complex with AP5A

PDB ID 1z83

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OCA

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