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1kke

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{{Seed}}
 
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[[Image:1kke.png|left|200px]]
 
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==Crystal Structure of Reovirus Attachment Protein Sigma1 Trimer==
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The line below this paragraph, containing "STRUCTURE_1kke", creates the "Structure Box" on the page.
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<StructureSection load='1kke' size='340' side='right'caption='[[1kke]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kke]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3_Dearing Mammalian orthoreovirus 3 Dearing]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KKE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kke OCA], [https://pdbe.org/1kke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kke RCSB], [https://www.ebi.ac.uk/pdbsum/1kke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kke ProSAT]</span></td></tr>
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{{STRUCTURE_1kke| PDB=1kke | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SIGM1_REOVD SIGM1_REOVD] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/1kke_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kke ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Reovirus Attachment Protein Sigma1 Trimer===
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==See Also==
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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<!--
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_11782420}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 11782420 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Mammalian orthoreovirus 3 Dearing]]
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{{ABSTRACT_PUBMED_11782420}}
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[[Category: Chappell JD]]
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[[Category: Dermody TS]]
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==About this Structure==
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[[Category: Prota AE]]
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1KKE is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKE OCA].
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[[Category: Stehle T]]
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==Reference==
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<ref group="xtra">PMID:11782420</ref><references group="xtra"/>
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[[Category: Reovirus sp.]]
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[[Category: Chappell, J D.]]
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[[Category: Dermody, T S.]]
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[[Category: Prota, A E.]]
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[[Category: Stehle, T.]]
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[[Category: Beta-barrel]]
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[[Category: Beta-spiral]]
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[[Category: Fiber]]
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[[Category: Receptor-binding]]
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[[Category: Reovirus]]
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[[Category: Sigma1]]
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[[Category: Trimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:13:06 2009''
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Current revision

Crystal Structure of Reovirus Attachment Protein Sigma1 Trimer

PDB ID 1kke

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