1g6z

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{{Seed}}
 
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[[Image:1g6z.png|left|200px]]
 
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==SOLUTION STRUCTURE OF THE CLR4 CHROMO DOMAIN==
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The line below this paragraph, containing "STRUCTURE_1g6z", creates the "Structure Box" on the page.
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<StructureSection load='1g6z' size='340' side='right'caption='[[1g6z]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1g6z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G6Z FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g6z OCA], [https://pdbe.org/1g6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g6z RCSB], [https://www.ebi.ac.uk/pdbsum/1g6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g6z ProSAT]</span></td></tr>
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{{STRUCTURE_1g6z| PDB=1g6z | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CLR4_SCHPO CLR4_SCHPO] Histone methyltransferase. Catalytic component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci.<ref>PMID:16024659</ref> <ref>PMID:8138176</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/1g6z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g6z ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The encapsulation of otherwise transcribable loci within transcriptionally inactive heterochromatin is rapidly gaining recognition as an important mechanism of epigenetic gene regulation. In the fission yeast Schizosaccharomyces pombe, heterochromatinization of the mat2/mat3 loci silences the mating-type information encoded within these loci. Here, we present the solution structure of the chromo domain from the cryptic loci regulator protein Clr4. Clr4 is known to regulate silencing and switching at the mating-type loci and to affect chromatin structure at centromeres. Clr4 and its human and Drosophila homologs have been identified as histone H3-specific methyltransferases, further implicating this family of proteins in chromatin remodeling. Our structure highlights a conserved surface that may be involved in chromo domain-ligand interactions. We have also analyzed two chromo domain mutants (W31G and W41G) that previously were shown to affect silencing and switching in full-length Clr4. Both mutants are significantly destabilized relative to wild-type.
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===SOLUTION STRUCTURE OF THE CLR4 CHROMO DOMAIN===
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Solution structure, domain features, and structural implications of mutants of the chromo domain from the fission yeast histone methyltransferase Clr4.,Horita DA, Ivanova AV, Altieri AS, Klar AJ, Byrd RA J Mol Biol. 2001 Mar 30;307(3):861-70. PMID:11273706<ref>PMID:11273706</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11273706}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1g6z" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11273706 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11273706}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1G6Z is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6Z OCA].
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==Reference==
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<ref group="xtra">PMID:11273706</ref><references group="xtra"/>
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[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
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[[Category: Altieri, A S.]]
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[[Category: Altieri AS]]
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[[Category: Byrd, R A.]]
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[[Category: Byrd RA]]
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[[Category: Horita, D A.]]
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[[Category: Horita DA]]
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[[Category: Ivanova, A V.]]
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[[Category: Ivanova AV]]
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[[Category: Klar, A J.]]
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[[Category: Klar AJ]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:16:17 2009''
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Current revision

SOLUTION STRUCTURE OF THE CLR4 CHROMO DOMAIN

PDB ID 1g6z

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