1jb1

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{{Seed}}
 
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[[Image:1jb1.png|left|200px]]
 
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==Lactobacillus casei HprK/P Bound to Phosphate==
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The line below this paragraph, containing "STRUCTURE_1jb1", creates the "Structure Box" on the page.
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<StructureSection load='1jb1' size='340' side='right'caption='[[1jb1]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jb1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JB1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1jb1| PDB=1jb1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jb1 OCA], [https://pdbe.org/1jb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jb1 RCSB], [https://www.ebi.ac.uk/pdbsum/1jb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jb1 ProSAT]</span></td></tr>
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</table>
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===Lactobacillus casei HprK/P Bound to Phosphate===
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== Function ==
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[https://www.uniprot.org/uniprot/HPRK_LACCA HPRK_LACCA] Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of 'Ser-46' in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.[HAMAP-Rule:MF_01249]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11483495}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11483495 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/1jb1_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11483495}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1JB1 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JB1 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jb1 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:11483495</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Lactobacillus casei]]
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[[Category: Lacticaseibacillus casei]]
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[[Category: Deutscher, J.]]
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[[Category: Large Structures]]
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[[Category: Fieulaine, S.]]
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[[Category: Deutscher J]]
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[[Category: Galinier, A.]]
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[[Category: Fieulaine S]]
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[[Category: Gueguen-Chaignon, V.]]
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[[Category: Galinier A]]
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[[Category: Janin, J.]]
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[[Category: Gueguen-Chaignon V]]
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[[Category: Monedero, V.]]
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[[Category: Janin J]]
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[[Category: Morera, S.]]
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[[Category: Monedero V]]
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[[Category: Nessler, S.]]
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[[Category: Morera S]]
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[[Category: Poncet, S.]]
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[[Category: Nessler S]]
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[[Category: Catabolite repression]]
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[[Category: Poncet S]]
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[[Category: Hexamer]]
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[[Category: Hpr phosphorylation]]
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[[Category: Lactobacillus casei]]
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[[Category: P-loop]]
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[[Category: Protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:19:00 2009''
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Current revision

Lactobacillus casei HprK/P Bound to Phosphate

PDB ID 1jb1

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