1d2t

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{{Seed}}
 
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[[Image:1d2t.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF ACID PHOSPHATASE FROM ESCHERICHIA BLATTAE==
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The line below this paragraph, containing "STRUCTURE_1d2t", creates the "Structure Box" on the page.
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<StructureSection load='1d2t' size='340' side='right'caption='[[1d2t]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1d2t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Shimwellia_blattae Shimwellia blattae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D2T FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1d2t| PDB=1d2t | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d2t OCA], [https://pdbe.org/1d2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d2t RCSB], [https://www.ebi.ac.uk/pdbsum/1d2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d2t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9S1A6_SHIBL Q9S1A6_SHIBL]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/1d2t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d2t ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of Escherichia blattae non-specific acid phosphatase (EB-NSAP) has been determined at 1.9 A resolution with a bound sulfate marking the phosphate-binding site. The enzyme is a 150 kDa homohexamer. EB-NSAP shares a conserved sequence motif not only with several lipid phosphatases and the mammalian glucose-6-phosphatases, but also with the vanadium-containing chloroperoxidase (CPO) of Curvularia inaequalis. Comparison of the crystal structures of EB-NSAP and CPO reveals striking similarity in the active site structures. In addition, the topology of the EB-NSAP core shows considerable similarity to the fold of the active site containing part of the monomeric 67 kDa CPO, despite the lack of further sequence identity. These two enzymes are apparently related by divergent evolution. We have also determined the crystal structure of EB-NSAP complexed with the transition-state analog molybdate. Structural comparison of the native enzyme and the enzyme-molybdate complex reveals that the side-chain of His150, a putative catalytic residue, moves toward the molybdate so that it forms a hydrogen bond with the metal oxyanion when the molybdenum forms a covalent bond with NE2 of His189.
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===CRYSTAL STRUCTURE OF ACID PHOSPHATASE FROM ESCHERICHIA BLATTAE===
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X-ray structures of a novel acid phosphatase from Escherichia blattae and its complex with the transition-state analog molybdate.,Ishikawa K, Mihara Y, Gondoh K, Suzuki E, Asano Y EMBO J. 2000 Jun 1;19(11):2412-23. PMID:10835340<ref>PMID:10835340</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1d2t" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10835340}}, adds the Publication Abstract to the page
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*[[Acid phosphatase 3D structures|Acid phosphatase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10835340 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10835340}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1D2T is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_blattae Escherichia blattae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2T OCA].
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[[Category: Shimwellia blattae]]
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[[Category: Asano Y]]
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==Reference==
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[[Category: Gondoh K]]
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<ref group="xtra">PMID:10835340</ref><references group="xtra"/>
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[[Category: Ishikawa K]]
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[[Category: Acid phosphatase]]
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[[Category: Mihara Y]]
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[[Category: Escherichia blattae]]
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[[Category: Suzuki E]]
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[[Category: Asano, Y.]]
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[[Category: Gondoh, K.]]
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[[Category: Ishikawa, K.]]
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[[Category: Mihara, Y.]]
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[[Category: Suzuki, E.]]
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[[Category: All alpha]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:21:20 2009''
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Current revision

CRYSTAL STRUCTURE OF ACID PHOSPHATASE FROM ESCHERICHIA BLATTAE

PDB ID 1d2t

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