2gw1

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[[Image:2gw1.png|left|200px]]
 
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==Crystal Structure of the Yeast Tom70==
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The line below this paragraph, containing "STRUCTURE_2gw1", creates the "Structure Box" on the page.
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<StructureSection load='2gw1' size='340' side='right'caption='[[2gw1]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GW1 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TOM70, MAS70, OMP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gw1 OCA], [https://pdbe.org/2gw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gw1 RCSB], [https://www.ebi.ac.uk/pdbsum/2gw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gw1 ProSAT]</span></td></tr>
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{{STRUCTURE_2gw1| PDB=2gw1 | SCENE= }}
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/TOM70_YEAST TOM70_YEAST]] Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.<ref>PMID:11054285</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/2gw1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gw1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A majority of the proteins targeted to the mitochondria are transported through the translocase of the outer membrane (TOM) complex. Tom70 is a major surface receptor for mitochondrial protein precursors in the TOM complex. To investigate how Tom70 receives the mitochondrial protein precursors, we have determined the crystal structure of yeast Tom70p to 3.0 A. Tom70p forms a homodimer in the crystal. Each subunit consists primarily of tetratricopeptide repeat (TPR) motifs, which are organized into a right-handed superhelix. The TPR motifs in the N-terminal domain of Tom70p form a peptide-binding groove for the C-terminal EEVD motif of Hsp70, whereas the C-terminal domain of Tom70p contains a large pocket that may be the binding site for mitochondrial precursors. The crystal structure of Tom70p provides insights into the mechanisms of precursor transport across the mitochondrion's outer membrane.
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===Crystal Structure of the Yeast Tom70===
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Crystal structure of yeast mitochondrial outer membrane translocon member Tom70p.,Wu Y, Sha B Nat Struct Mol Biol. 2006 Jul;13(7):589-93. Epub 2006 Jun 11. PMID:16767096<ref>PMID:16767096</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2gw1" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16767096 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16767096}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Atcc 18824]]
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2GW1 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GW1 OCA].
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[[Category: Large Structures]]
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[[Category: Sha, B]]
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==Reference==
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[[Category: Wu, Y]]
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<ref group="xtra">PMID:16767096</ref><references group="xtra"/>
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[[Category: Protein transport]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Sha, B.]]
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[[Category: Wu, Y.]]
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[[Category: Tpr]]
[[Category: Tpr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:36:36 2009''
 

Current revision

Crystal Structure of the Yeast Tom70

PDB ID 2gw1

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