4eug

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{{Seed}}
 
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[[Image:4eug.png|left|200px]]
 
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==Crystallographic and Enzymatic Studies of an Active Site Variant H187Q of Escherichia Coli Uracil DNA Glycosylase: Crystal Structures of Mutant H187Q and its Uracil Complex==
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The line below this paragraph, containing "STRUCTURE_4eug", creates the "Structure Box" on the page.
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<StructureSection load='4eug' size='340' side='right'caption='[[4eug]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4eug]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_B Escherichia coli B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EUG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eug OCA], [https://pdbe.org/4eug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eug RCSB], [https://www.ebi.ac.uk/pdbsum/4eug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eug ProSAT]</span></td></tr>
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{{STRUCTURE_4eug| PDB=4eug | SCENE= }}
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</table>
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== Function ==
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===CRYSTALLOGRAPHIC AND ENZYMATIC STUDIES OF AN ACTIVE SITE VARIANT H187Q OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE: CRYSTAL STRUCTURES OF MUTANT H187Q AND ITS URACIL COMPLEX===
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[https://www.uniprot.org/uniprot/UNG_ECOLI UNG_ECOLI] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.[HAMAP-Rule:MF_00148]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_10090282}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 10090282 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/4eug_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_10090282}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4eug ConSurf].
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4EUG is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUG OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:10090282</ref><references group="xtra"/>
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[[Category: Escherichia coli B]]
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Uridine nucleosidase]]
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[[Category: Drohat AC]]
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[[Category: Drohat, A C.]]
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[[Category: Gilliland GL]]
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[[Category: Gilliland, G L.]]
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[[Category: Jagadeesh J]]
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[[Category: Jagadeesh, J.]]
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[[Category: Stivers JT]]
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[[Category: Stivers, J T.]]
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[[Category: Tordova M]]
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[[Category: Tordova, M.]]
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[[Category: Xiao G]]
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[[Category: Xiao, G.]]
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[[Category: Glycosylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:38:57 2009''
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Current revision

Crystallographic and Enzymatic Studies of an Active Site Variant H187Q of Escherichia Coli Uracil DNA Glycosylase: Crystal Structures of Mutant H187Q and its Uracil Complex

PDB ID 4eug

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OCA

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