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2o2h

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{{Seed}}
 
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[[Image:2o2h.png|left|200px]]
 
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==Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,2-dichloroethane==
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The line below this paragraph, containing "STRUCTURE_2o2h", creates the "Structure Box" on the page.
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<StructureSection load='2o2h' size='340' side='right'caption='[[2o2h]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2o2h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DCE:1,2-DICHLOROETHANE'>DCE</scene></td></tr>
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{{STRUCTURE_2o2h| PDB=2o2h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2h OCA], [https://pdbe.org/2o2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2h RCSB], [https://www.ebi.ac.uk/pdbsum/2o2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DHAA_MYCTU DHAA_MYCTU] Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity).[HAMAP-Rule:MF_01231]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o2h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o2h ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,2-dichloroethane===
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==See Also==
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*[[Dehalogenase 3D structures|Dehalogenase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2O2H is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2H OCA].
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[[Category: Large Structures]]
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[[Category: Haloalkane dehalogenase]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Cherney MM]]
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[[Category: Cherney, M M.]]
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[[Category: Garen CR]]
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[[Category: Garen, C R.]]
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[[Category: Hulecki J]]
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[[Category: Hulecki, J.]]
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[[Category: James MNG]]
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[[Category: James, M N.G.]]
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[[Category: Mazumdar PA]]
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[[Category: Mazumdar, P A.]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: 1,2-dichloroethane]]
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[[Category: Alpha/beta-hydrolase protein]]
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[[Category: Haloalkane dehalogenase]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Rv2579]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:39:21 2009''
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Current revision

Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,2-dichloroethane

PDB ID 2o2h

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