1p72

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{{Seed}}
 
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[[Image:1p72.png|left|200px]]
 
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==Crystal structure of EHV4-TK complexed with Thy and ADP==
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The line below this paragraph, containing "STRUCTURE_1p72", creates the "Structure Box" on the page.
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<StructureSection load='1p72' size='340' side='right'caption='[[1p72]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1p72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equid_alphaherpesvirus_4 Equid alphaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P72 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
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{{STRUCTURE_1p72| PDB=1p72 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p72 OCA], [https://pdbe.org/1p72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p72 RCSB], [https://www.ebi.ac.uk/pdbsum/1p72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p72 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KITH_EHV4 KITH_EHV4] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/1p72_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p72 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Crystal structures of equine herpesvirus type-4 thymidine kinase (EHV4-TK) in complex with (i). thymidine and ADP, (ii). thymidine and SO(4) and the bisubstrate analogs, (iii). TP(4)A, and (iv). TP(5)A have been solved. Additionally, the structure of herpes simplex virus type-1 thymidine kinase (HSV1-TK) in complex with TP(5)A has been determined. These are the first structures of nucleoside kinases revealing conformational transitions upon binding of bisubstrate analogs. The structural basis for the dual thymidine and thymidylate kinase activity of these TKs is elucidated. While the active sites of HSV1-TK and EHV4-TK resemble one another, notable differences are observed in the Lid regions and in the way the enzymes bind the base of the phosphoryl-acceptor. The latter difference could partly explain the higher activity of EHV4-TK toward the prodrug ganciclovir.
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===Crystal structure of EHV4-TK complexed with Thy and ADP===
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Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.,Gardberg A, Shuvalova L, Monnerjahn C, Konrad M, Lavie A Structure. 2003 Oct;11(10):1265-77. PMID:14527394<ref>PMID:14527394</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1p72" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14527394}}, adds the Publication Abstract to the page
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*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14527394 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14527394}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Equid alphaherpesvirus 4]]
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1P72 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Equid_herpesvirus_4 Equid herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P72 OCA].
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[[Category: Large Structures]]
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[[Category: Gardberg A]]
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==Reference==
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[[Category: Konrad M]]
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<ref group="xtra">PMID:14527394</ref><references group="xtra"/>
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[[Category: Lavie A]]
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[[Category: Equid herpesvirus 4]]
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[[Category: Monnerjahn C]]
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[[Category: Thymidine kinase]]
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[[Category: Shuvalova L]]
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[[Category: Gardberg, A.]]
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[[Category: Konrad, M.]]
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[[Category: Lavie, A.]]
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[[Category: Monnerjahn, C.]]
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[[Category: Shuvalova, L.]]
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[[Category: Lid]]
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[[Category: P-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:50:41 2009''
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Current revision

Crystal structure of EHV4-TK complexed with Thy and ADP

PDB ID 1p72

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