1tqe

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{{Seed}}
 
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[[Image:1tqe.png|left|200px]]
 
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==Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2==
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The line below this paragraph, containing "STRUCTURE_1tqe", creates the "Structure Box" on the page.
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<StructureSection load='1tqe' size='340' side='right'caption='[[1tqe]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tqe]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqe OCA], [https://pdbe.org/1tqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tqe RCSB], [https://www.ebi.ac.uk/pdbsum/1tqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tqe ProSAT]</span></td></tr>
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{{STRUCTURE_1tqe| PDB=1tqe | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MEF2B_HUMAN MEF2B_HUMAN] Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tqe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tqe ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Class II histone deacetylases (HDACs) bind myocyte enhancer factor-2 (MEF2) and repress specific gene expression in a calcium-dependent manner. Despite their significant physiological functions in muscle, immune and neuronal cells, the mechanism of recruitment of class II HDACs by MEF2 is not well understood. Here, we have characterized the complex between the MEF2-binding motif of class II HDACs and the MADS-box/MEF2S domain of MEF2B by structural and biochemical methods. The crystal structure of a HDAC9/MEF2/DNA complex reveals that HDAC9 binds to a hydrophobic groove of the MEF2 dimer. The overall binding mode is similar to that seen in the Cabin1/MEF2/DNA complex. The detailed binding interactions at the HDAC9/MEF2 interface, however, show marked differences from those at the Cabin1/MEF2 interface. Our studies suggest a general mechanism by which class II HDACs and possibly other transcriptional co-regulators are recruited by MEF2. On the other hand, the differential binding between MEF2 and its various partners may confer specific regulatory and functional properties to MEF2 in distinct cellular processes. Such specificity provides a basis for selectively disrupting a particular MEF2/co-regulator complex by mutations or small molecules.
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===Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2===
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Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2.,Han A, He J, Wu Y, Liu JO, Chen L J Mol Biol. 2005 Jan 7;345(1):91-102. PMID:15567413<ref>PMID:15567413</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1tqe" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15567413}}, adds the Publication Abstract to the page
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15567413 is the PubMed ID number.
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*[[Myocyte enhancer factor 2|Myocyte enhancer factor 2]]
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== References ==
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{{ABSTRACT_PUBMED_15567413}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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1TQE is a 10 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQE OCA].
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==Reference==
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<ref group="xtra">PMID:15567413</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Chen, L.]]
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[[Category: Chen L]]
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[[Category: Han, A.]]
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[[Category: Han A]]
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[[Category: He, J.]]
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[[Category: He J]]
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[[Category: Liu, J O.]]
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[[Category: Liu JO]]
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[[Category: Wu, Y.]]
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[[Category: Wu Y]]
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[[Category: Co-repressor]]
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[[Category: Hdac]]
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[[Category: Mef2]]
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[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:52:27 2009''
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Current revision

Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2

PDB ID 1tqe

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