2a8c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:20, 23 August 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2a8c.png|left|200px]]
 
-
<!--
+
==Haemophilus influenzae beta-carbonic anhydrase==
-
The line below this paragraph, containing "STRUCTURE_2a8c", creates the "Structure Box" on the page.
+
<StructureSection load='2a8c' size='340' side='right'caption='[[2a8c]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2a8c]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A8C FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_2a8c| PDB=2a8c | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a8c OCA], [https://pdbe.org/2a8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a8c RCSB], [https://www.ebi.ac.uk/pdbsum/2a8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a8c ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CAN_HAEIN CAN_HAEIN]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/2a8c_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a8c ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The structures of beta class carbonic anhydrases (beta-CAs) determined so far fall into two distinct subclasses based on the observed coordination of the catalytic zinc (Zn2+) ion. The subclass of beta-CAs that coordinate Zn2+ tetrahedrally with four protein-derived ligands is represented by the structures of orthologues from Porphyridium purpureum, Escherichia coli, and Mycobacterium tuberculosis. Here we present the structure of an additional member of that subclass, that from Haemophilus influenzae, as well as detailed kinetic analysis, revealing the correspondence between structural classification and kinetic profile for this subclass. In addition, we identify a unique, noncatalytic binding mode for the substrate bicarbonate that occurs in both the H. influenzae and E. coli enzymes. The kinetic and structural analysis indicates that binding of bicarbonate in this site of the enzyme may modulate its activity by influencing a pH-dependent, cooperative transition between active and inactive forms. We hypothesize that the two structural subclasses of beta-CAs may provide models for the proposed active and inactive forms of the H. influenzae and E. coli enzymes.
-
===Haemophilus influenzae beta-carbonic anhydrase===
+
Identification of a novel noncatalytic bicarbonate binding site in eubacterial beta-carbonic anhydrase.,Cronk JD, Rowlett RS, Zhang KY, Tu C, Endrizzi JA, Lee J, Gareiss PC, Preiss JR Biochemistry. 2006 Apr 11;45(14):4351-61. PMID:16584170<ref>PMID:16584170</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2a8c" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_16584170}}, adds the Publication Abstract to the page
+
*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 16584170 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_16584170}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2A8C is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A8C OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:16584170</ref><references group="xtra"/>
+
-
[[Category: Carbonate dehydratase]]
+
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
-
[[Category: Cronk, J D.]]
+
[[Category: Large Structures]]
-
[[Category: Endrizzi, J A.]]
+
[[Category: Cronk JD]]
-
[[Category: Gareiss, P C.]]
+
[[Category: Endrizzi JA]]
-
[[Category: Lee, J.]]
+
[[Category: Gareiss PC]]
-
[[Category: Preiss, J R.]]
+
[[Category: Lee J]]
-
[[Category: Rowlett, R S.]]
+
[[Category: Preiss JR]]
-
[[Category: Tu, C.]]
+
[[Category: Rowlett RS]]
-
[[Category: Zhang, K Y.J.]]
+
[[Category: Tu C]]
-
[[Category: Carbonic anhydrase]]
+
[[Category: Zhang KYJ]]
-
[[Category: X-ray structure]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:00:50 2009''
+

Current revision

Haemophilus influenzae beta-carbonic anhydrase

PDB ID 2a8c

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2a8c"
Personal tools