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1crc

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{{Seed}}
 
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[[Image:1crc.png|left|200px]]
 
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==CYTOCHROME C AT LOW IONIC STRENGTH==
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The line below this paragraph, containing "STRUCTURE_1crc", creates the "Structure Box" on the page.
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<StructureSection load='1crc' size='340' side='right'caption='[[1crc]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1crc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CRC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
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{{STRUCTURE_1crc| PDB=1crc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1crc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1crc OCA], [https://pdbe.org/1crc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1crc RCSB], [https://www.ebi.ac.uk/pdbsum/1crc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1crc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYC_HORSE CYC_HORSE] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/1crc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1crc ConSurf].
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<div style="clear:both"></div>
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===CYTOCHROME C AT LOW IONIC STRENGTH===
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==See Also==
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*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8591047}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8591047 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8591047}}
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==About this Structure==
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1CRC is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CRC OCA].
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==Reference==
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<ref group="xtra">PMID:8591047</ref><references group="xtra"/>
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[[Category: Equus caballus]]
[[Category: Equus caballus]]
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[[Category: Margoliash, E.]]
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[[Category: Large Structures]]
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[[Category: Sanishvili, R.]]
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[[Category: Margoliash E]]
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[[Category: Volz, K W.]]
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[[Category: Sanishvili R]]
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[[Category: Westbrook, E M.]]
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[[Category: Volz KW]]
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[[Category: Ferric form]]
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[[Category: Westbrook EM]]
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[[Category: Low ionic strength]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:16:42 2009''
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Current revision

CYTOCHROME C AT LOW IONIC STRENGTH

PDB ID 1crc

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