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2esa

From Proteopedia

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{{Seed}}
 
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[[Image:2esa.png|left|200px]]
 
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==GRP94 n-terminal domain bound to geldanamycin: effects of mutants 168-169 KS-AA==
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The line below this paragraph, containing "STRUCTURE_2esa", creates the "Structure Box" on the page.
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<StructureSection load='2esa' size='340' side='right'caption='[[2esa]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2esa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ESA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDM:GELDANAMYCIN'>GDM</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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{{STRUCTURE_2esa| PDB=2esa | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2esa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2esa OCA], [https://pdbe.org/2esa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2esa RCSB], [https://www.ebi.ac.uk/pdbsum/2esa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2esa ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/2esa_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2esa ConSurf].
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<div style="clear:both"></div>
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===GRP94 n-terminal domain bound to geldanamycin: effects of mutants 168-169 KS-AA===
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2ESA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESA OCA].
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[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
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[[Category: Gewirth, D T.]]
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[[Category: Large Structures]]
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[[Category: IV, L E.Metzger.]]
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[[Category: Gewirth DT]]
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[[Category: Immormino, R M.]]
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[[Category: Immormino RM]]
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[[Category: Grp94 gp96 hsp90 bergerat chaperone endoplasmic reticulum geldanamycin 17-aag]]
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[[Category: Metzger IV LE]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:27:44 2009''
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Current revision

GRP94 n-terminal domain bound to geldanamycin: effects of mutants 168-169 KS-AA

PDB ID 2esa

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