1anv

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{{Seed}}
 
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[[Image:1anv.png|left|200px]]
 
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==ADENOVIRUS 5 DBP/URANYL FLUORIDE SOAK==
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The line below this paragraph, containing "STRUCTURE_1anv", creates the "Structure Box" on the page.
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<StructureSection load='1anv' size='340' side='right'caption='[[1anv]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1anv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_5 Human adenovirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ANV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ANV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IUM:URANYL+(VI)+ION'>IUM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1anv| PDB=1anv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1anv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1anv OCA], [https://pdbe.org/1anv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1anv RCSB], [https://www.ebi.ac.uk/pdbsum/1anv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1anv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DNB2_ADE05 DNB2_ADE05] Binds cooperatively single-stranded DNA in a sequence-independent manner. Involved in DNA-replication, regulation of mRNA formation, and host-range specificity. Zinc is required for DNA binding.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/1anv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1anv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Soaking crystals of the C-terminal DNA-binding domain of the adenovirus single-stranded DNA-binding protein with a buffer containing K(3)UO(2)F(5) results in a 9% change of the crystallographic c axis without destruction of the crystals or appreciable loss of resolution. The crystals belong to space group P2(1)2(1)2(1) with a = 79.7, b = 75.6 and c = 60.6 A. The three-dimensional structure has been refined to 2.7 A with a crystallographic R factor of 0.206. Antiparallel chains of protein molecules running through the entire crystal are linked by uranyl ions. The relative orientation of protein monomers is flexible, even in the crystalline state, and allows changes in the packing of the protein chains.
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===ADENOVIRUS 5 DBP/URANYL FLUORIDE SOAK===
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Conformational change of the adenovirus DNA-binding protein induced by soaking crystals with K3UO2F5 solutions.,Kanellopoulos PN, Tsernoglou D, van der Vliet PC, Tucker PA Acta Crystallogr D Biol Crystallogr. 1996 Sep 1;52(Pt 5):942-5. PMID:15299602<ref>PMID:15299602</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1anv" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15299602}}, adds the Publication Abstract to the page
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*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15299602 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15299602}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1ANV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_5 Human adenovirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ANV OCA].
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==Reference==
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<ref group="xtra">PMID:15299602</ref><references group="xtra"/>
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[[Category: Human adenovirus 5]]
[[Category: Human adenovirus 5]]
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[[Category: Kanellopoulos, P N.]]
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[[Category: Large Structures]]
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[[Category: Tsernoglou, D.]]
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[[Category: Kanellopoulos PN]]
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[[Category: Tucker, P A.]]
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[[Category: Tsernoglou D]]
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[[Category: Vliet, P C.Van Der.]]
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[[Category: Tucker PA]]
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[[Category: Dna-binding protein]]
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[[Category: Van Der Vliet PC]]
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[[Category: Early protein]]
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[[Category: Nuclear protein]]
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[[Category: Phosphorylation]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:30:04 2009''
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Current revision

ADENOVIRUS 5 DBP/URANYL FLUORIDE SOAK

PDB ID 1anv

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