1gsm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:23, 23 October 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1gsm.png|left|200px]]
 
-
<!--
+
==A reassessment of the MAdCAM-1 structure and its role in integrin recognition.==
-
The line below this paragraph, containing "STRUCTURE_1gsm", creates the "Structure Box" on the page.
+
<StructureSection load='1gsm' size='340' side='right'caption='[[1gsm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GSM FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [https://pdbe.org/1gsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [https://www.ebi.ac.uk/pdbsum/1gsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gsm ProSAT]</span></td></tr>
-
{{STRUCTURE_1gsm| PDB=1gsm | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MADCA_HUMAN MADCA_HUMAN] Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/1gsm_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gsm ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Mucosal addressin cell-adhesion molecule (MAdCAM-1) is a membrane-bound leukocyte receptor regulating both the passage and retention of leukocytes in mucosal tissues. A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1 has previously been reported, confirming their expected immunoglobulin superfamily topology. In this study, a second crystal structure of this fragment is described. Although the overall structure is similar to that previously reported, one edge strand in the amino-terminal domain is instead located on the opposite sheet. This alters the arrangement and conformation of amino acids in this region that have previously been shown to be crucial for ligand binding. MAdCAM-1 is also seen to form dimers within the crystal lattice, raising the possibility that oligomerization may influence the biological role of this adhesion molecule.
-
===A REASSESSMENT OF THE MADCAM-1 STRUCTURE AND ITS ROLE IN INTEGRIN RECOGNITION.===
+
A reassessment of the MAdCAM-1 structure and its role in integrin recognition.,Dando J, Wilkinson KW, Ortlepp S, King DJ, Brady RL Acta Crystallogr D Biol Crystallogr. 2002 Feb;58(Pt 2):233-41. Epub 2002, Jan 24. PMID:11807247<ref>PMID:11807247</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_11807247}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1gsm" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 11807247 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_11807247}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
1GSM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:11807247</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Brady, R L.]]
+
[[Category: Large Structures]]
-
[[Category: Dando, J.]]
+
[[Category: Brady RL]]
-
[[Category: King, D J.]]
+
[[Category: Dando J]]
-
[[Category: Ortlepp, S.]]
+
[[Category: King DJ]]
-
[[Category: Wilkinson, K W.]]
+
[[Category: Ortlepp S]]
-
[[Category: Cell adhesion glycoprotein]]
+
[[Category: Wilkinson KW]]
-
[[Category: Cell adhesion protein]]
+
-
[[Category: I-set fold]]
+
-
[[Category: Immunoglobulin fold]]
+
-
[[Category: Integrin recoginition]]
+
-
[[Category: Madcam-1]]
+
-
[[Category: Membrane protein]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:31:19 2009''
+

Current revision

A reassessment of the MAdCAM-1 structure and its role in integrin recognition.

PDB ID 1gsm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gsm"
Personal tools