1s9u

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{{Seed}}
 
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[[Image:1s9u.png|left|200px]]
 
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==Atomic structure of a putative anaerobic dehydrogenase component==
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The line below this paragraph, containing "STRUCTURE_1s9u", creates the "Structure Box" on the page.
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<StructureSection load='1s9u' size='340' side='right'caption='[[1s9u]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1s9u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S9U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1s9u| PDB=1s9u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s9u OCA], [https://pdbe.org/1s9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s9u RCSB], [https://www.ebi.ac.uk/pdbsum/1s9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s9u ProSAT], [https://www.topsan.org/Proteins/MCSG/1s9u TOPSAN]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s9/1s9u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s9u ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The DmsD protein is necessary for the biogenesis of dimethyl sulphoxide (DMSO) reductase in many prokaryotes. It performs a critical chaperone function initiated through its binding to the twin-arginine signal peptide of DmsA, the catalytic subunit of DMSO reductase. Upon binding to DmsD, DmsA is translocated to the periplasm via the so-called twin-arginine translocation (Tat) pathway. Here we report the 1.38 A crystal structure of the protein DmsD from Salmonella typhimurium and compare it with a close functional homolog, TorD. DmsD has an all-alpha fold structure with a notable helical extension located at its N-terminus with two solvent exposed hydrophobic residues. A major difference between DmsD and TorD is that TorD structure is a domain-swapped dimer, while DmsD exists as a monomer. Nevertheless, these two proteins have a number of common features suggesting they function by using similar mechanisms. A possible signal peptide-binding site is proposed based on structural similarities. Computational analysis was used to identify a potential GTP binding pocket on similar surfaces of DmsD and TorD structures.
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===Atomic structure of a putative anaerobic dehydrogenase component===
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The 1.38 A crystal structure of DmsD protein from Salmonella typhimurium, a proofreading chaperone on the Tat pathway.,Qiu Y, Zhang R, Binkowski TA, Tereshko V, Joachimiak A, Kossiakoff A Proteins. 2008 May 1;71(2):525-33. PMID:18175314<ref>PMID:18175314</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18175314}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1s9u" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18175314 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18175314}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1S9U is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium_lt2 Salmonella typhimurium lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9U OCA].
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Collart F]]
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==Reference==
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[[Category: Joachimiak A]]
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<ref group="xtra">PMID:18175314</ref><references group="xtra"/>
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[[Category: Kim Y]]
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[[Category: Salmonella typhimurium lt2]]
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[[Category: Kossiakoff A]]
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[[Category: Collart, F.]]
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[[Category: Qiu Y]]
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[[Category: Joachimiak, A.]]
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[[Category: Tereshko V]]
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[[Category: Kim, Y.]]
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[[Category: Zhang R]]
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[[Category: Kossiakoff, A.]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Qiu, Y.]]
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[[Category: Tereshko, V.]]
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[[Category: Zhang, R.]]
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[[Category: Anaerobic dehydrogenases component]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:34:02 2009''
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Current revision

Atomic structure of a putative anaerobic dehydrogenase component

PDB ID 1s9u

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