1js6

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{{Seed}}
 
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[[Image:1js6.png|left|200px]]
 
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==Crystal Structure of DOPA decarboxylase==
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The line below this paragraph, containing "STRUCTURE_1js6", creates the "Structure Box" on the page.
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<StructureSection load='1js6' size='340' side='right'caption='[[1js6]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1js6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JS6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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{{STRUCTURE_1js6| PDB=1js6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1js6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js6 OCA], [https://pdbe.org/1js6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1js6 RCSB], [https://www.ebi.ac.uk/pdbsum/1js6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1js6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DDC_PIG DDC_PIG] Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1js6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1js6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DOPA decarboxylase (DDC) is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively. DDC has been implicated in a number of clinic disorders, including Parkinson's disease and hypertension. Peripheral inhibitors of DDC are currently used to treat these diseases. We present the crystal structures of ligand-free DDC and its complex with the anti-Parkinson drug carbiDOPA. The inhibitor is bound to the enzyme by forming a hydrazone linkage with the cofactor, and its catechol ring is deeply buried in the active site cleft. The structures provide the molecular basis for the development of new inhibitors of DDC with better pharmacological characteristics.
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===Crystal Structure of DOPA decarboxylase===
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Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase.,Burkhard P, Dominici P, Borri-Voltattorni C, Jansonius JN, Malashkevich VN Nat Struct Biol. 2001 Nov;8(11):963-7. PMID:11685243<ref>PMID:11685243</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1js6" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11685243}}, adds the Publication Abstract to the page
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*[[DOPA decarboxylase|DOPA decarboxylase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11685243 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11685243}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1JS6 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS6 OCA].
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==Reference==
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<ref group="xtra">PMID:11685243</ref><references group="xtra"/>
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[[Category: Aromatic-L-amino-acid decarboxylase]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Borri-Voltattorni, C.]]
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[[Category: Borri-Voltattorni C]]
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[[Category: Burkhard, P.]]
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[[Category: Burkhard P]]
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[[Category: Dominici, P.]]
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[[Category: Dominici P]]
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[[Category: Jansonius, J N.]]
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[[Category: Jansonius JN]]
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[[Category: Malashkevich, V N.]]
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[[Category: Malashkevich VN]]
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[[Category: Carbidopa]]
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[[Category: Dopa decarboxylase]]
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[[Category: Parkinson's disease]]
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[[Category: Vitamin b6]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:40:16 2009''
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Current revision

Crystal Structure of DOPA decarboxylase

PDB ID 1js6

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