1id4

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{{Seed}}
 
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[[Image:1id4.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT (H157Q) OF THE HUMAN CYTOMEGALOVIRUS PROTEASE==
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The line below this paragraph, containing "STRUCTURE_1id4", creates the "Structure Box" on the page.
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<StructureSection load='1id4' size='340' side='right'caption='[[1id4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1id4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_AD169 Human herpesvirus 5 strain AD169]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ID4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ID4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1id4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1id4 OCA], [https://pdbe.org/1id4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1id4 RCSB], [https://www.ebi.ac.uk/pdbsum/1id4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1id4 ProSAT]</span></td></tr>
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{{STRUCTURE_1id4| PDB=1id4 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SCAF_HCMVA SCAF_HCMVA] Capsid scaffolding protein acts as a scaffold protein by binding major capsid protein UL86 in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein UL86. Cleavages products are evicted from the capsid before or during DNA packaging (By similarity). Assemblin is a protease essential for virion assembly in the nucleus. Catalyzes the cleavage of the assembly protein after complete capsid formation. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging (By similarity). Assembly protein plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein UL86. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/1id4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1id4 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT (H157Q) OF THE HUMAN CYTOMEGALOVIRUS PROTEASE===
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==See Also==
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*[[Virus protease 3D structures|Virus protease 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11371196}}, adds the Publication Abstract to the page
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[[Category: Human herpesvirus 5 strain AD169]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11371196 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Batra R]]
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{{ABSTRACT_PUBMED_11371196}}
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[[Category: Khayat R]]
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[[Category: Lagace L]]
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==About this Structure==
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[[Category: Massariol MJ]]
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1ID4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_herpesvirus_5 Human herpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ID4 OCA].
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[[Category: Tong L]]
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==Reference==
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<ref group="xtra">PMID:11371196</ref><references group="xtra"/>
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[[Category: Assemblin]]
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[[Category: Human herpesvirus 5]]
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[[Category: Batra, R.]]
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[[Category: Khayat, R.]]
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[[Category: Lagace, L.]]
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[[Category: Massariol, M J.]]
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[[Category: Tong, L.]]
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[[Category: Coat protein]]
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[[Category: Hydrolase]]
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[[Category: Phosphorylation]]
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[[Category: Serine protease]]
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[[Category: Viral protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:47:59 2009''
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Current revision

CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT (H157Q) OF THE HUMAN CYTOMEGALOVIRUS PROTEASE

PDB ID 1id4

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