1oll

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{{Seed}}
 
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[[Image:1oll.png|left|200px]]
 
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==Extracellular region of the human receptor NKp46==
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The line below this paragraph, containing "STRUCTURE_1oll", creates the "Structure Box" on the page.
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<StructureSection load='1oll' size='340' side='right'caption='[[1oll]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1oll]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OLL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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{{STRUCTURE_1oll| PDB=1oll | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oll OCA], [https://pdbe.org/1oll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oll RCSB], [https://www.ebi.ac.uk/pdbsum/1oll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oll ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCTR1_HUMAN NCTR1_HUMAN] Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.<ref>PMID:9730896</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ol/1oll_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oll ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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NKp46, a natural killer (NK) cell-specific receptor, has been recently identified as one of the triggering receptors involved in NK cell activation mediated by non-HLA class I ligands. The structure of the NKp46 extracellular receptor region, here reported, consists of two Ig-like domains assembled similarly to leukocyte immunoglobulin-like receptors (LIRs) and killer inhibitory receptors (KIRs). The extensive NKp46 residue substitutions at sites structurally related to those mediating interaction with HLA antigens in LIRs and KIRs indicate that NKp46 recognition processes in vivo should involve non-HLA ligands. NKP46 is shown to stem from an ancestral KIR/LIR family. However, the absence of close paralogues, such as those found for LIR and KIR, indicates that NKp46 is the unique member of a distinct Ig-like subfamily and suggests a specific role, which appears to be maintained across primates and rodents.
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===EXTRACELLULAR REGION OF THE HUMAN RECEPTOR NKP46===
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Structure of the human NK cell triggering receptor NKp46 ectodomain.,Ponassi M, Cantoni C, Biassoni R, Conte R, Spallarossa A, Pesce A, Moretta A, Moretta L, Bolognesi M, Bordo D Biochem Biophys Res Commun. 2003 Sep 19;309(2):317-23. PMID:12951052<ref>PMID:12951052</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1oll" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12951052}}, adds the Publication Abstract to the page
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*[[NK cell receptor|NK cell receptor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12951052 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12951052}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Homo sapiens]]
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1OLL is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLL OCA].
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[[Category: Large Structures]]
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[[Category: Biassoni R]]
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==Reference==
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[[Category: Bolognesi M]]
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<ref group="xtra">PMID:12951052</ref><references group="xtra"/>
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[[Category: Bordo D]]
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[[Category: Escherichia coli]]
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[[Category: Cantoni C]]
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[[Category: Biassoni, R.]]
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[[Category: Conte R]]
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[[Category: Bolognesi, M.]]
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[[Category: Moretta A]]
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[[Category: Bordo, D.]]
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[[Category: Moretta L]]
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[[Category: Cantoni, C.]]
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[[Category: Pesce A]]
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[[Category: Conte, R.]]
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[[Category: Ponassi M]]
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[[Category: Moretta, A.]]
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[[Category: Spallarossa A]]
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[[Category: Moretta, L.]]
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[[Category: Pesce, A.]]
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[[Category: Ponassi, M.]]
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[[Category: Spallarossa, A.]]
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[[Category: Cytotoxicity,c2-type ig-like domain]]
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[[Category: Ig domain]]
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[[Category: Immune system]]
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[[Category: Nk cell triggering receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:50:51 2009''
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Current revision

Extracellular region of the human receptor NKp46

PDB ID 1oll

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