2ftu

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{{Seed}}
 
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[[Image:2ftu.png|left|200px]]
 
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==solution structure of domain 3 of RAP==
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The line below this paragraph, containing "STRUCTURE_2ftu", creates the "Structure Box" on the page.
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<StructureSection load='2ftu' size='340' side='right'caption='[[2ftu]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ftu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FTU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ftu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ftu OCA], [https://pdbe.org/2ftu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ftu RCSB], [https://www.ebi.ac.uk/pdbsum/2ftu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ftu ProSAT]</span></td></tr>
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{{STRUCTURE_2ftu| PDB=2ftu | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN] Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.
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== Function ==
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[https://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN] Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ftu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ftu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The receptor associated protein (RAP) is an antagonist and molecular chaperone that binds tightly to low-density lipoprotein receptor family members in the endoplasmic reticulum (ER). After escorting these receptors to the Golgi, RAP dissociates from the receptors. The molecular mechanism of the dissociation has been unknown until now. The solution structure of RAP-D3 domain presented here reveals a striking increase in positively charged residues on the surface of this RAP domain due to protonation of solvent-exposed histidine sidechains as the pH is reduced from a near neutral pH of the ER to the acidic pH of the Golgi. Structure-based mutagenesis studies in vitro and in cells confirm that the protonation of histidine residues as a consequence of the pH changes modulate the binding/release of RAP from LRP. This histidine switch may serve as a general mechanism for regulating cell trafficking events.
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===solution structure of domain 3 of RAP===
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RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi.,Lee D, Walsh JD, Mikhailenko I, Yu P, Migliorini M, Wu Y, Krueger S, Curtis JE, Harris B, Lockett S, Blacklow SC, Strickland DK, Wang YX Mol Cell. 2006 May 5;22(3):423-30. PMID:16678114<ref>PMID:16678114</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16678114}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2ftu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16678114 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16678114}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2FTU is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTU OCA].
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==Reference==
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<ref group="xtra">PMID:16678114</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Lee, D.]]
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[[Category: Large Structures]]
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[[Category: Walsh, J D.]]
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[[Category: Lee D]]
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[[Category: Wang, Y X.]]
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[[Category: Walsh JD]]
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[[Category: Domain 3]]
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[[Category: Wang Y-X]]
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[[Category: Rap]]
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[[Category: Receptor-associated protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:53:50 2009''
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Current revision

solution structure of domain 3 of RAP

PDB ID 2ftu

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