2ofn

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{{Seed}}
 
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[[Image:2ofn.png|left|200px]]
 
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==Solution structure of FK506-binding domain (FKBD)of FKBP35 from Plasmodium falciparum==
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The line below this paragraph, containing "STRUCTURE_2ofn", creates the "Structure Box" on the page.
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<StructureSection load='2ofn' size='340' side='right'caption='[[2ofn]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ofn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OFN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ofn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ofn OCA], [https://pdbe.org/2ofn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ofn RCSB], [https://www.ebi.ac.uk/pdbsum/2ofn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ofn ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_2ofn| PDB=2ofn | SCENE= }}
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== Function ==
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[https://www.uniprot.org/uniprot/FKB35_PLAF7 FKB35_PLAF7] Has peptidylprolyl isomerase (PPIase) and co-chaperone activities (PubMed:15664653, PubMed:15850699). Assists protein folding by catalyzing the peptidyl conversion of cis and trans rotamers of the prolyl amide bond of protein substrates (PubMed:15664653, PubMed:15850699, PubMed:23974147). Inhibits calcineurin phosphatase activity in vitro (PubMed:15850699, PubMed:17289400, PubMed:23974147). Plays an essential role in merozoite egress from host erythrocytes (PubMed:15664653, PubMed:23974147).<ref>PMID:15664653</ref> <ref>PMID:15850699</ref> <ref>PMID:17289400</ref> <ref>PMID:23974147</ref>
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===Solution structure of FK506-binding domain (FKBD)of FKBP35 from Plasmodium falciparum===
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==About this Structure==
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<jmolCheckbox>
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2OFN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFN OCA].
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/of/2ofn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==Reference==
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<text>to colour the structure by Evolutionary Conservation</text>
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<ref group="xtra">PMID:17876830</ref><references group="xtra"/>
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</jmolCheckbox>
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[[Category: Peptidylprolyl isomerase]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ofn ConSurf].
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[[Category: Plasmodium falciparum]]
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<div style="clear:both"></div>
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[[Category: Kang, C B.]]
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== References ==
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[[Category: Ye, H.]]
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<references/>
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[[Category: Yoon, H R.]]
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__TOC__
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[[Category: Yoon, H S.]]
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</StructureSection>
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[[Category: Beta barrel]]
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[[Category: Large Structures]]
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[[Category: Central helix]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Isomerase]]
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[[Category: Kang CB]]
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[[Category: Ye H]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:59:24 2009''
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[[Category: Yoon HR]]
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[[Category: Yoon HS]]

Current revision

Solution structure of FK506-binding domain (FKBD)of FKBP35 from Plasmodium falciparum

PDB ID 2ofn

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