This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ofn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:02, 14 June 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2ofn.png|left|200px]]
 
-
<!--
+
==Solution structure of FK506-binding domain (FKBD)of FKBP35 from Plasmodium falciparum==
-
The line below this paragraph, containing "STRUCTURE_2ofn", creates the "Structure Box" on the page.
+
<StructureSection load='2ofn' size='340' side='right'caption='[[2ofn]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2ofn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OFN FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ofn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ofn OCA], [https://pdbe.org/2ofn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ofn RCSB], [https://www.ebi.ac.uk/pdbsum/2ofn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ofn ProSAT]</span></td></tr>
-
-->
+
</table>
-
{{STRUCTURE_2ofn| PDB=2ofn | SCENE= }}
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/FKB35_PLAF7 FKB35_PLAF7] Has peptidylprolyl isomerase (PPIase) and co-chaperone activities (PubMed:15664653, PubMed:15850699). Assists protein folding by catalyzing the peptidyl conversion of cis and trans rotamers of the prolyl amide bond of protein substrates (PubMed:15664653, PubMed:15850699, PubMed:23974147). Inhibits calcineurin phosphatase activity in vitro (PubMed:15850699, PubMed:17289400, PubMed:23974147). Plays an essential role in merozoite egress from host erythrocytes (PubMed:15664653, PubMed:23974147).<ref>PMID:15664653</ref> <ref>PMID:15850699</ref> <ref>PMID:17289400</ref> <ref>PMID:23974147</ref>
-
===Solution structure of FK506-binding domain (FKBD)of FKBP35 from Plasmodium falciparum===
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
==About this Structure==
+
<jmolCheckbox>
-
2OFN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFN OCA].
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/of/2ofn_consurf.spt"</scriptWhenChecked>
-
 
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
==Reference==
+
<text>to colour the structure by Evolutionary Conservation</text>
-
<ref group="xtra">PMID:17876830</ref><references group="xtra"/>
+
</jmolCheckbox>
-
[[Category: Peptidylprolyl isomerase]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ofn ConSurf].
-
[[Category: Plasmodium falciparum]]
+
<div style="clear:both"></div>
-
[[Category: Kang, C B.]]
+
== References ==
-
[[Category: Ye, H.]]
+
<references/>
-
[[Category: Yoon, H R.]]
+
__TOC__
-
[[Category: Yoon, H S.]]
+
</StructureSection>
-
[[Category: Beta barrel]]
+
[[Category: Large Structures]]
-
[[Category: Central helix]]
+
[[Category: Plasmodium falciparum 3D7]]
-
[[Category: Isomerase]]
+
[[Category: Kang CB]]
-
 
+
[[Category: Ye H]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:59:24 2009''
+
[[Category: Yoon HR]]
 +
[[Category: Yoon HS]]

Current revision

Solution structure of FK506-binding domain (FKBD)of FKBP35 from Plasmodium falciparum

PDB ID 2ofn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ofn"
Personal tools