1tzl

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{{Seed}}
 
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[[Image:1tzl.png|left|200px]]
 
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==Crystal Structure of Pyranose 2-Oxidase from the White-Rot Fungus Peniophora sp.==
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The line below this paragraph, containing "STRUCTURE_1tzl", creates the "Structure Box" on the page.
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<StructureSection load='1tzl' size='340' side='right'caption='[[1tzl]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tzl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Peniophora_sp._SG Peniophora sp. SG]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TZL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1tzl| PDB=1tzl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tzl OCA], [https://pdbe.org/1tzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tzl RCSB], [https://www.ebi.ac.uk/pdbsum/1tzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tzl ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tz/1tzl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tzl ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pyranose 2-oxidase catalyzes the oxidation of a number of carbohydrates using dioxygen. The enzyme forms a D(2) symmetric homotetramer and contains one covalently bound FAD per subunit. The structure of the enzyme from Peniophora sp. was determined by multiwavelength anomalous diffraction (MAD) based on 96 selenium sites per crystallographic asymmetric unit and subsequently refined to good-quality indices. According to its chain fold, the enzyme belongs to the large glutathione reductase family and, in a more narrow sense, to the glucose-methanol-choline oxidoreductase (GMC) family. The tetramer contains a spacious central cavity from which the substrate enters one of the four active centers by penetrating a mobile barrier. Since this cavity can only be accessed by glucose-sized molecules, the enzyme does not convert sugars that are part of a larger molecule. The geometry of the active center and a comparison with an inhibitor complex of the homologous enzyme cellobiose dehydrogenase allow the modeling of the reaction at a high confidence level.
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===Crystal Structure of Pyranose 2-Oxidase from the White-Rot Fungus Peniophora sp.===
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Crystal structure of pyranose 2-oxidase from the white-rot fungus Peniophora sp.,Bannwarth M, Bastian S, Heckmann-Pohl D, Giffhorn F, Schulz GE Biochemistry. 2004 Sep 21;43(37):11683-90. PMID:15362852<ref>PMID:15362852</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1tzl" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15362852}}, adds the Publication Abstract to the page
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*[[Pyranose oxidase|Pyranose oxidase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15362852 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15362852}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1TZL is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Peniophora_sp._sg Peniophora sp. sg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TZL OCA].
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[[Category: Peniophora sp. SG]]
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[[Category: Bannwarth M]]
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==Reference==
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[[Category: Bastian S]]
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<ref group="xtra">PMID:15362852</ref><references group="xtra"/>
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[[Category: Giffhorn F]]
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[[Category: Peniophora sp. sg]]
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[[Category: Heckmann-Pohl D]]
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[[Category: Pyranose oxidase]]
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[[Category: Schulz GE]]
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[[Category: Bannwarth, M.]]
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[[Category: Bastian, S.]]
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[[Category: Giffhorn, F.]]
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[[Category: Heckmann-Pohl, D.]]
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[[Category: Schulz, G E.]]
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[[Category: Glucose-methanol-choline family]]
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[[Category: Gmc oxidoreductase]]
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[[Category: Large inner cavity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:05:16 2009''
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Current revision

Crystal Structure of Pyranose 2-Oxidase from the White-Rot Fungus Peniophora sp.

PDB ID 1tzl

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