1u4f

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{{Seed}}
 
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[[Image:1u4f.png|left|200px]]
 
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==Crystal Structure of Cytoplasmic Domains of IRK1 (Kir2.1) channel==
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The line below this paragraph, containing "STRUCTURE_1u4f", creates the "Structure Box" on the page.
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<StructureSection load='1u4f' size='340' side='right'caption='[[1u4f]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1u4f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U4F FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u4f OCA], [https://pdbe.org/1u4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u4f RCSB], [https://www.ebi.ac.uk/pdbsum/1u4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u4f ProSAT]</span></td></tr>
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{{STRUCTURE_1u4f| PDB=1u4f | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCNJ2_MOUSE KCNJ2_MOUSE] Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u4/1u4f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u4f ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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N- and C-terminal cytoplasmic domains of inwardly rectifying K (Kir) channels control the ion-permeation pathway through diverse interactions with small molecules and protein ligands in the cytoplasm. Two new crystal structures of the cytoplasmic domains of Kir2.1 (Kir2.1(L)) and the G protein-sensitive Kir3.1 (Kir3.1(S)) channels in the absence of PIP(2) show the cytoplasmic ion-permeation pathways occluded by four cytoplasmic loops that form a girdle around the central pore (G-loop). Significant flexibility of the pore-facing G-loop of Kir2.1(L) and Kir3.1(S) suggests a possible role as a diffusion barrier between cytoplasmic and transmembrane pores. Consistent with this, mutations of the G-loop disrupted gating or inward rectification. Structural comparison shows a di-aspartate cluster on the distal end of the cytoplasmic pore of Kir2.1(L) that is important for modulating inward rectification. Taken together, these results suggest the cytoplasmic domains of Kir channels undergo structural changes to modulate gating and inward rectification.
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===Crystal Structure of Cytoplasmic Domains of IRK1 (Kir2.1) channel===
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Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification.,Pegan S, Arrabit C, Zhou W, Kwiatkowski W, Collins A, Slesinger PA, Choe S Nat Neurosci. 2005 Mar;8(3):279-87. Epub 2005 Feb 20. PMID:15723059<ref>PMID:15723059</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1u4f" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15723059}}, adds the Publication Abstract to the page
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15723059 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15723059}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1U4F is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U4F OCA].
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==Reference==
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<ref group="xtra">PMID:15723059</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Arrabit, C.]]
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[[Category: Arrabit C]]
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[[Category: Choe, S.]]
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[[Category: Choe S]]
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[[Category: Kwiatkowski, W.]]
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[[Category: Kwiatkowski W]]
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[[Category: Pegan, S.]]
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[[Category: Pegan S]]
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[[Category: Slesinger, P A.]]
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[[Category: Slesinger PA]]
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[[Category: Zhou, W.]]
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[[Category: Zhou W]]
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[[Category: Cytoplasmic domain]]
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[[Category: Inwardly rectifying k channel]]
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[[Category: Irk1]]
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[[Category: Kir2 1]]
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[[Category: Rectification]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:09:46 2009''
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Current revision

Crystal Structure of Cytoplasmic Domains of IRK1 (Kir2.1) channel

PDB ID 1u4f

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