1u35

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:37, 23 August 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1u35.png|left|200px]]
 
-
<!--
+
==Crystal structure of the nucleosome core particle containing the histone domain of macroH2A==
-
The line below this paragraph, containing "STRUCTURE_1u35", creates the "Structure Box" on the page.
+
<StructureSection load='1u35' size='340' side='right'caption='[[1u35]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1u35]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U35 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u35 OCA], [https://pdbe.org/1u35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u35 RCSB], [https://www.ebi.ac.uk/pdbsum/1u35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u35 ProSAT]</span></td></tr>
-
{{STRUCTURE_1u35| PDB=1u35 | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/H31_MOUSE H31_MOUSE]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u35_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u35 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
macroH2A is an H2A variant with a highly unusual structural organization. It has a C-terminal domain connected to the N-terminal histone domain by a linker. Crystallographic and biochemical studies show that changes in the L1 loop in the histone fold region of macroH2A impact the structure and potentially the function of nucleosomes. The 1.6-A X-ray structure of the nonhistone region reveals an alpha/beta fold which has previously been found in a functionally diverse group of proteins. This region associates with histone deacetylases and affects the acetylation status of nucleosomes containing macroH2A. Thus, the unusual domain structure of macroH2A integrates independent functions that are instrumental in establishing a structurally and functionally unique chromatin domain.
-
===Crystal structure of the nucleosome core particle containing the histone domain of macroH2A===
+
Structural characterization of the histone variant macroH2A.,Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K Mol Cell Biol. 2005 Sep;25(17):7616-24. PMID:16107708<ref>PMID:16107708</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1u35" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_16107708}}, adds the Publication Abstract to the page
+
*[[Histone 3D structures|Histone 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 16107708 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_16107708}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
1U35 is a 10 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U35 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:16107708</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Caron, C.]]
+
[[Category: Caron C]]
-
[[Category: Chakravarthy, S.]]
+
[[Category: Chakravarthy S]]
-
[[Category: Gundimella, S K.]]
+
[[Category: Gundimella SK]]
-
[[Category: Khochbin, S.]]
+
[[Category: Khochbin S]]
-
[[Category: Luger, K.]]
+
[[Category: Luger K]]
-
[[Category: Pehrson, J R.]]
+
[[Category: Pehrson JR]]
-
[[Category: Perche, P Y.]]
+
[[Category: Perche PY]]
-
[[Category: Histone fold]]
+
-
[[Category: Histone variant]]
+
-
[[Category: Macroh2a]]
+
-
[[Category: Ncp]]
+
-
[[Category: Nucleosome]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:12:36 2009''
+

Current revision

Crystal structure of the nucleosome core particle containing the histone domain of macroH2A

PDB ID 1u35

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1u35"
Personal tools