1nnv

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{{Seed}}
 
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[[Image:1nnv.png|left|200px]]
 
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==The Solution structure of HI1450==
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The line below this paragraph, containing "STRUCTURE_1nnv", creates the "Structure Box" on the page.
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<StructureSection load='1nnv' size='340' side='right'caption='[[1nnv]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nnv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NNV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nnv OCA], [https://pdbe.org/1nnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nnv RCSB], [https://www.ebi.ac.uk/pdbsum/1nnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nnv ProSAT]</span></td></tr>
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{{STRUCTURE_1nnv| PDB=1nnv | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Y1450_HAEIN Y1450_HAEIN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/1nnv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nnv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of the acidic protein HI1450 from Haemophilus influenzae has been determined by NMR spectroscopy. HI1450 has homologues in ten other bacterial species including Escherichia coli, Vibrio cholerae, and Yersinia pestis but there are no functional assignments for any members of the family. Thirty-one of the amino acids in this 107-residue protein are aspartates or glutamates, contributing to an unusually low pI of 3.72. The secondary structure elements are arranged in an alpha-alpha-beta-beta-beta-beta order with the two alpha helices packed against the same side of an anti-parallel four-stranded beta meander. Two large loops, one between beta1 and beta2 and the other between beta2 and beta3 bend almost perpendicularly across the beta-strands in opposite directions on the non-helical side of the beta-sheet to form a conserved hydrophobic cavity. The HI1450 structure has some similarities to the structure of the double-stranded DNA (dsDNA) mimic uracil DNA glycosylase inhibitor (Ugi) including the distribution of surface charges and the position of the hydrophobic cavity. Based on these similarities, as well as having a comparable molecular surface to dsDNA, we propose that HI1450 may function as a dsDNA mimic in order to inhibit or regulate an as yet unidentified dsDNA binding protein.
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===The Solution structure of HI1450===
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Solution structure of the highly acidic protein HI1450 from Haemophilus influenzae, a putative double-stranded DNA mimic.,Parsons LM, Yeh DC, Orban J Proteins. 2004 Feb 15;54(3):375-83. PMID:14747986<ref>PMID:14747986</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14747986}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1nnv" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14747986 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14747986}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1NNV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNV OCA].
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==Reference==
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<ref group="xtra">PMID:14747986</ref><references group="xtra"/>
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[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Orban, J.]]
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[[Category: Large Structures]]
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[[Category: Parsons, L M.]]
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[[Category: Orban J]]
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[[Category: S2F, Structure 2.Function Project.]]
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[[Category: Parsons LM]]
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[[Category: Hypothetical protein]]
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[[Category: S2f]]
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[[Category: Structural genomic]]
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[[Category: Structure 2 function project]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:48:05 2009''
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Current revision

The Solution structure of HI1450

PDB ID 1nnv

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OCA

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