2ane

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{{Seed}}
 
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[[Image:2ane.png|left|200px]]
 
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==Crystal structure of N-terminal domain of E.Coli Lon Protease==
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The line below this paragraph, containing "STRUCTURE_2ane", creates the "Structure Box" on the page.
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<StructureSection load='2ane' size='340' side='right'caption='[[2ane]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ane]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ANE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ane FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ane OCA], [https://pdbe.org/2ane PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ane RCSB], [https://www.ebi.ac.uk/pdbsum/2ane PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ane ProSAT]</span></td></tr>
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{{STRUCTURE_2ane| PDB=2ane | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of N-terminal domain of E.Coli Lon Protease===
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[https://www.uniprot.org/uniprot/LON_ECOLI LON_ECOLI] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins, including some antitoxins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system.<ref>PMID:12135363</ref> <ref>PMID:16584195</ref> <ref>PMID:19721064</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/2ane_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_16199667}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ane ConSurf].
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2ANE is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANE OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:16199667</ref><references group="xtra"/>
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__TOC__
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[[Category: Endopeptidase La]]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Gustchina, A.]]
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[[Category: Large Structures]]
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[[Category: Li, M.]]
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[[Category: Gustchina A]]
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[[Category: Maurizi, M R.]]
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[[Category: Li M]]
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[[Category: Melnikov, E E.]]
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[[Category: Maurizi MR]]
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[[Category: Rasulova, F.]]
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[[Category: Melnikov EE]]
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[[Category: Rotanova, T V.]]
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[[Category: Rasulova F]]
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[[Category: Wlodawer, A.]]
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[[Category: Rotanova TV]]
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[[Category: Lon protease]]
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[[Category: Wlodawer A]]
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[[Category: Lonn119]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:50:24 2009''
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Current revision

Crystal structure of N-terminal domain of E.Coli Lon Protease

PDB ID 2ane

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