1ckv

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{{Seed}}
 
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[[Image:1ckv.png|left|200px]]
 
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==STRUCTURE OF THE SOLUBLE METHANE MONOOXYGENASE REGULATORY PROTEIN B==
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The line below this paragraph, containing "STRUCTURE_1ckv", creates the "Structure Box" on the page.
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<StructureSection load='1ckv' size='340' side='right'caption='[[1ckv]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ckv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ckv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckv OCA], [https://pdbe.org/1ckv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ckv RCSB], [https://www.ebi.ac.uk/pdbsum/1ckv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckv ProSAT]</span></td></tr>
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{{STRUCTURE_1ckv| PDB=1ckv | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMOB_METCA MMOB_METCA] The B protein acts as a regulator of electron flow through the soluble mmo complex, switching the enzyme from an oxidase to a hydroxylase in the presence of the substrate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/1ckv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ckv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The soluble methane monooxygenase (sMMO; EC 1.14.13.25) from the pseudothermophile Methylococcus capsulatus (Bath) is a three-component enzyme system that catalyzes the selective oxidation of methane to methanol. We have used NMR spectroscopy to produce a highly refined structure of MMOB, the 16-kDa regulatory protein of this system. This structure has a unique and intricate fold containing seven beta-strands forming two beta-sheets oriented perpendicular to each other and bridged by three alpha-helices. The rate and efficiency of the methane hydroxylation by sMMO depend on dynamic binding interactions of the hydroxylase with the reductase and regulatory protein components during catalysis. We have monitored by NMR the binding of MMOB to the hydroxylase in the presence and absence of the reductase. The results of these studies provide structural insight into how the regulatory protein interacts with the hydroxylase.
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===STRUCTURE OF THE SOLUBLE METHANE MONOOXYGENASE REGULATORY PROTEIN B===
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Structure of the soluble methane monooxygenase regulatory protein B.,Walters KJ, Gassner GT, Lippard SJ, Wagner G Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7877-82. PMID:10393915<ref>PMID:10393915</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1ckv" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10393915}}, adds the Publication Abstract to the page
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*[[Methane monooxygenase 3D structures|Methane monooxygenase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10393915 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10393915}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1CKV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKV OCA].
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==Reference==
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<ref group="xtra">PMID:10393915</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Gassner, G T.]]
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[[Category: Large Structures]]
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[[Category: Lippard, S J.]]
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[[Category: Gassner GT]]
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[[Category: Wagner, G.]]
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[[Category: Lippard SJ]]
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[[Category: Walters, K J.]]
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[[Category: Wagner G]]
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[[Category: Hydroxylase regulatory protein]]
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[[Category: Walters KJ]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:55:54 2009''
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Current revision

STRUCTURE OF THE SOLUBLE METHANE MONOOXYGENASE REGULATORY PROTEIN B

PDB ID 1ckv

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