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2b6g

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(New page: 200px<br /><applet load="2b6g" size="450" color="white" frame="true" align="right" spinBox="true" caption="2b6g" /> '''RNA recognition by the Vts1 SAM domain'''<br...)
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[[Image:2b6g.gif|left|200px]]<br /><applet load="2b6g" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2b6g" />
 
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'''RNA recognition by the Vts1 SAM domain'''<br />
 
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==Overview==
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==RNA recognition by the Vts1 SAM domain==
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The putative yeast post-transcriptional regulator Vts1p and its related, protein Smaug, from Drosophila melanogaster, each use a sterile alpha, motif (SAM) domain to bind an RNA hairpin termed the Smaug recognition, element (SRE). Here, we present the NMR structures of the Vts1p-SRE, complex and the free SRE. Structural highlights include the direct, recognition of a guanine base and the formation or stabilization of a base, pair in the SRE loop.
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<StructureSection load='2b6g' size='340' side='right'caption='[[2b6g]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2b6g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B6G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b6g OCA], [https://pdbe.org/2b6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b6g RCSB], [https://www.ebi.ac.uk/pdbsum/2b6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b6g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VTS1_YEAST VTS1_YEAST] RNA-binding protein involved in post-transcriptional regulation through transcript degradation of SRE (SMG-recognition elements) bearing mRNAs. May be involved in vacuolar protein transport.<ref>PMID:11445562</ref> <ref>PMID:12858164</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/2b6g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b6g ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The putative yeast post-transcriptional regulator Vts1p and its related protein Smaug, from Drosophila melanogaster, each use a sterile alpha motif (SAM) domain to bind an RNA hairpin termed the Smaug recognition element (SRE). Here, we present the NMR structures of the Vts1p-SRE complex and the free SRE. Structural highlights include the direct recognition of a guanine base and the formation or stabilization of a base pair in the SRE loop.
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==About this Structure==
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RNA recognition by the Vts1p SAM domain.,Johnson PE, Donaldson LW Nat Struct Mol Biol. 2006 Feb;13(2):177-8. Epub 2006 Jan 22. PMID:16429155<ref>PMID:16429155</ref>
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2B6G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2B6G OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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RNA recognition by the Vts1p SAM domain., Johnson PE, Donaldson LW, Nat Struct Mol Biol. 2006 Feb;13(2):177-8. Epub 2006 Jan 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16429155 16429155]
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</div>
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<div class="pdbe-citations 2b6g" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Donaldson LW]]
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[[Category: Donaldson, L.W.]]
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[[Category: Johnson PE]]
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[[Category: Johnson, P.E.]]
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[[Category: alpha-helix]]
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[[Category: hairpin]]
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[[Category: pentaloop]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 08:36:02 2007''
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Current revision

RNA recognition by the Vts1 SAM domain

PDB ID 2b6g

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