2de7

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{{Seed}}
 
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[[Image:2de7.png|left|200px]]
 
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==The substrate-bound complex between oxygenase and ferredoxin in carbazole 1,9a-dioxygenase==
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The line below this paragraph, containing "STRUCTURE_2de7", creates the "Structure Box" on the page.
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<StructureSection load='2de7' size='340' side='right'caption='[[2de7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2de7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Janthinobacterium Janthinobacterium] and [https://en.wikipedia.org/wiki/Pseudomonas_resinovorans Pseudomonas resinovorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DE7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9CA:9H-CARBAZOLE'>9CA</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene></td></tr>
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{{STRUCTURE_2de7| PDB=2de7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2de7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2de7 OCA], [https://pdbe.org/2de7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2de7 RCSB], [https://www.ebi.ac.uk/pdbsum/2de7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2de7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q84II6_JANS3 Q84II6_JANS3]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/2de7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2de7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Carbazole 1,9a-dioxygenase (CARDO), a member of the Rieske nonheme iron oxygenase system (ROS), consists of a terminal oxygenase (CARDO-O) and electron transfer components (ferredoxin [CARDO-F] and ferredoxin reductase [CARDO-R]). We determined the crystal structures of the nonreduced, reduced, and substrate-bound binary complexes of CARDO-O with its electron donor, CARDO-F, at 1.9, 1.8, and 2.0 A resolutions, respectively. These structures provide the first structure-based interpretation of intercomponent electron transfer between two Rieske [2Fe-2S] clusters of ferredoxin and oxygenase in ROS. Three molecules of CARDO-F bind to the subunit boundary of one CARDO-O trimeric molecule, and specific binding created by electrostatic and hydrophobic interactions with conformational changes suitably aligns the two Rieske clusters for electron transfer. Additionally, conformational changes upon binding carbazole resulted in the closure of a lid over the substrate-binding pocket, thereby seemingly trapping carbazole at the substrate-binding site.
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===The substrate-bound complex between oxygenase and ferredoxin in carbazole 1,9a-dioxygenase===
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Electron transfer complex formation between oxygenase and ferredoxin components in Rieske nonheme iron oxygenase system.,Ashikawa Y, Fujimoto Z, Noguchi H, Habe H, Omori T, Yamane H, Nojiri H Structure. 2006 Dec;14(12):1779-89. PMID:17161368<ref>PMID:17161368</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2de7" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17161368}}, adds the Publication Abstract to the page
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17161368 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17161368}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2DE7 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Janthinobacterium Janthinobacterium] and [http://en.wikipedia.org/wiki/Pseudomonas_resinovorans Pseudomonas resinovorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DE7 OCA].
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==Reference==
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<ref group="xtra">PMID:17161368</ref><references group="xtra"/>
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[[Category: Janthinobacterium]]
[[Category: Janthinobacterium]]
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[[Category: Large Structures]]
[[Category: Pseudomonas resinovorans]]
[[Category: Pseudomonas resinovorans]]
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[[Category: Ashikawa, Y.]]
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[[Category: Ashikawa Y]]
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[[Category: Nojiri, H.]]
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[[Category: Nojiri H]]
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[[Category: Carbazole 1,9a-dioxygenase]]
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[[Category: Electron transfer complex]]
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[[Category: Rieske non-heme iron oxygenase system]]
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[[Category: Rieske-type ferredoxin]]
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[[Category: Terminal oxygenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:02:26 2009''
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Current revision

The substrate-bound complex between oxygenase and ferredoxin in carbazole 1,9a-dioxygenase

PDB ID 2de7

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