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2qtu

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{{Seed}}
 
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[[Image:2qtu.png|left|200px]]
 
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<!--
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==Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand==
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The line below this paragraph, containing "STRUCTURE_2qtu", creates the "Structure Box" on the page.
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<StructureSection load='2qtu' size='340' side='right'caption='[[2qtu]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2qtu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QTU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3AS:(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL'>3AS</scene></td></tr>
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{{STRUCTURE_2qtu| PDB=2qtu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qtu OCA], [https://pdbe.org/2qtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qtu RCSB], [https://www.ebi.ac.uk/pdbsum/2qtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qtu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/2qtu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qtu ConSurf].
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<div style="clear:both"></div>
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===Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand===
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==See Also==
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*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_17804226}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17804226 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_17804226}}
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==About this Structure==
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2QTU is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QTU OCA].
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==Reference==
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<ref group="xtra">PMID:17804226</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dodge, J A.]]
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[[Category: Large Structures]]
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[[Category: Durbin, J D.]]
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[[Category: Dodge JA]]
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[[Category: Krishnan, V.]]
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[[Category: Durbin JD]]
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[[Category: Norman, B H.]]
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[[Category: Krishnan V]]
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[[Category: Richardson, T I.]]
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[[Category: Norman BH]]
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[[Category: Wang, Y.]]
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[[Category: Richardson TI]]
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[[Category: Alternative splicing]]
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[[Category: Wang Y]]
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[[Category: Dna-binding]]
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[[Category: Ligand-binding domain]]
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[[Category: Lipid-binding]]
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[[Category: Metal-binding]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: Steroid-binding]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription regulator]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:13:41 2009''
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Current revision

Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand

PDB ID 2qtu

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