2b7m

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{{Seed}}
 
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[[Image:2b7m.png|left|200px]]
 
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==Crystal Structure of the S. cerevisiae Exocyst Component Exo70p==
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The line below this paragraph, containing "STRUCTURE_2b7m", creates the "Structure Box" on the page.
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<StructureSection load='2b7m' size='340' side='right'caption='[[2b7m]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2b7m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B7M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2b7m| PDB=2b7m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7m OCA], [https://pdbe.org/2b7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b7m RCSB], [https://www.ebi.ac.uk/pdbsum/2b7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b7m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EXO70_YEAST EXO70_YEAST] Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in the assembly of the exocyst.<ref>PMID:15583030</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/2b7m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b7m ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The exocyst is an evolutionarily conserved multiprotein complex required for the targeting and docking of post-Golgi vesicles to the plasma membrane. Through its interactions with a variety of proteins, including small GTPases, the exocyst is thought to integrate signals from the cell and signal that vesicles arriving at the plasma membrane are ready for fusion. Here we describe the three-dimensional crystal structure of one of the components of the exocyst, Exo70p, from Saccharomyces cerevisiae at 3.5A resolution. Exo70p binds the small GTPase Rho3p in a GTP-dependent manner with an equilibrium dissociation constant of approximately 70 microM. Exo70p is an extended rod approximately 155 angstroms in length composed principally of alpha helices, and is a novel fold. The structure provides a first view of the Exo70 protein family and provides a framework to study the molecular function of this exocyst component.
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===Crystal Structure of the S. cerevisiae Exocyst Component Exo70p===
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Crystal structure of the S.cerevisiae exocyst component Exo70p.,Hamburger ZA, Hamburger AE, West AP Jr, Weis WI J Mol Biol. 2006 Feb 10;356(1):9-21. Epub 2005 Nov 10. PMID:16359701<ref>PMID:16359701</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16359701}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2b7m" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16359701 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16359701}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2B7M is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7M OCA].
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==Reference==
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<ref group="xtra">PMID:16359701</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Hamburger, A E.]]
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[[Category: Hamburger AE]]
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[[Category: Hamburger, Z A.]]
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[[Category: Hamburger ZA]]
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[[Category: Weis, W I.]]
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[[Category: Weis WI]]
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[[Category: West, A P.]]
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[[Category: West AP]]
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[[Category: Exocyst]]
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[[Category: Exocytosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:13:52 2009''
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Current revision

Crystal Structure of the S. cerevisiae Exocyst Component Exo70p

PDB ID 2b7m

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