1go3

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{{Seed}}
 
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[[Image:1go3.png|left|200px]]
 
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==Structure of an archeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex==
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The line below this paragraph, containing "STRUCTURE_1go3", creates the "Structure Box" on the page.
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<StructureSection load='1go3' size='340' side='right'caption='[[1go3]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1go3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GO3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GO3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1go3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1go3 OCA], [https://pdbe.org/1go3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1go3 RCSB], [https://www.ebi.ac.uk/pdbsum/1go3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1go3 ProSAT]</span></td></tr>
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{{STRUCTURE_1go3| PDB=1go3 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RPO7_METJA RPO7_METJA] DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_00865]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/1go3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1go3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The eukaryotic subunits RPB4 and RPB7 form a heterodimer that reversibly associates with the RNA polymerase II core and constitute the only two components of the enzyme for which no structural information is available. We have determined the crystal structure of the complex between the Methanococcus jannaschii subunits E and F, the archaeal homologs of RPB7 and RPB4. Subunit E has an elongated two-domain structure and contains two potential RNA binding motifs, while the smaller F subunit wraps around one side of subunit E, at the interface between the two domains. We propose a model for the interaction between RPB4/RPB7 and the core RNA polymerase in which the RNA binding face of RPB7 is positioned to interact with the nascent RNA transcript.
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===STRUCTURE OF AN ARCHEAL HOMOLOG OF THE EUKARYOTIC RNA POLYMERASE II RPB4/RPB7 COMPLEX===
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Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex.,Todone F, Brick P, Werner F, Weinzierl RO, Onesti S Mol Cell. 2001 Nov;8(5):1137-43. PMID:11741548<ref>PMID:11741548</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1go3" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11741548}}, adds the Publication Abstract to the page
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11741548 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11741548}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1GO3 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GO3 OCA].
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==Reference==
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<ref group="xtra">PMID:11741548</ref><references group="xtra"/>
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Brick, P.]]
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[[Category: Brick P]]
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[[Category: Onesti, S.]]
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[[Category: Onesti S]]
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[[Category: Todone, F.]]
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[[Category: Todone F]]
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[[Category: Weinzierl, R O.J.]]
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[[Category: Weinzierl ROJ]]
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[[Category: Werner, F.]]
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[[Category: Werner F]]
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[[Category: Dna-directed rna polymerase]]
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[[Category: Transcription]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:14:29 2009''
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Current revision

Structure of an archeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex

PDB ID 1go3

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