2b97

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(New page: 200px<br /><applet load="2b97" size="450" color="white" frame="true" align="right" spinBox="true" caption="2b97, resolution 0.75&Aring;" /> '''Ultra-high resolutio...)
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[[Image:2b97.gif|left|200px]]<br /><applet load="2b97" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2b97, resolution 0.75&Aring;" />
 
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'''Ultra-high resolution structure of hydrophobin HFBII'''<br />
 
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==Overview==
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==Ultra-high resolution structure of hydrophobin HFBII==
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Hydrophobins are small proteins secreted by filamentous fungi that have a, unique ability to spontaneously form amphiphilic layers. Hydrophobins have, only recently been structurally characterized through the first crystal, structure determination of a protein of this class, Trichoderma reesei, hydrophobin HFBII [Hakanpaa, Paananen et al. (2004), J. Biol. Chem. 279, 534-539]. The resolution of the HFBII structure has now been extended to, an ultrahigh resolution of 0.75 A. The structure was refined, conventionally and multipole refinement has been initiated. The, ultrahigh-resolution structure is analyzed here in detail and comparison, is made to the previous atomic resolution structure of the same protein as, well as to other ultrahigh-resolution structures found in the Protein Data, Bank.
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<StructureSection load='2b97' size='340' side='right'caption='[[2b97]], [[Resolution|resolution]] 0.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2b97]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoderma_reesei Trichoderma reesei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B97 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b97 OCA], [https://pdbe.org/2b97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b97 RCSB], [https://www.ebi.ac.uk/pdbsum/2b97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b97 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HYP2_HYPJE HYP2_HYPJE] Responsible for spore hydrophobicity and protection.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/2b97_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b97 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hydrophobins are small proteins secreted by filamentous fungi that have a unique ability to spontaneously form amphiphilic layers. Hydrophobins have only recently been structurally characterized through the first crystal structure determination of a protein of this class, Trichoderma reesei hydrophobin HFBII [Hakanpaa, Paananen et al. (2004), J. Biol. Chem. 279, 534-539]. The resolution of the HFBII structure has now been extended to an ultrahigh resolution of 0.75 A. The structure was refined conventionally and multipole refinement has been initiated. The ultrahigh-resolution structure is analyzed here in detail and comparison is made to the previous atomic resolution structure of the same protein as well as to other ultrahigh-resolution structures found in the Protein Data Bank.
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==About this Structure==
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Hydrophobin HFBII in detail: ultrahigh-resolution structure at 0.75 A.,Hakanpaa J, Linder M, Popov A, Schmidt A, Rouvinen J Acta Crystallogr D Biol Crystallogr. 2006 Apr;62(Pt 4):356-67. Epub 2006, Mar 18. PMID:16552136<ref>PMID:16552136</ref>
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2B97 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hypocrea_jecorina Hypocrea jecorina] with MN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2B97 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Hydrophobin HFBII in detail: ultrahigh-resolution structure at 0.75 A., Hakanpaa J, Linder M, Popov A, Schmidt A, Rouvinen J, Acta Crystallogr D Biol Crystallogr. 2006 Apr;62(Pt 4):356-67. Epub 2006, Mar 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16552136 16552136]
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</div>
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[[Category: Hypocrea jecorina]]
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<div class="pdbe-citations 2b97" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Hakanpaa, J.]]
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<references/>
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[[Category: Linder, M.]]
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__TOC__
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[[Category: Popov, A.]]
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</StructureSection>
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[[Category: Rouvinen, J.]]
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[[Category: Large Structures]]
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[[Category: Schmidt, A.]]
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[[Category: Trichoderma reesei]]
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[[Category: MN]]
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[[Category: Hakanpaa J]]
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[[Category: amphiphilic]]
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[[Category: Linder M]]
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[[Category: hydrophobin]]
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[[Category: Popov A]]
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[[Category: surfactant]]
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[[Category: Rouvinen J]]
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[[Category: ultra-high resolution]]
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[[Category: Schmidt A]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 08:38:57 2007''
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Current revision

Ultra-high resolution structure of hydrophobin HFBII

PDB ID 2b97

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