1i54

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{{Seed}}
 
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[[Image:1i54.png|left|200px]]
 
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==CYTOCHROME C (TUNA) 2FE:1ZN MIXED-METAL PORPHYRINS==
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The line below this paragraph, containing "STRUCTURE_1i54", creates the "Structure Box" on the page.
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<StructureSection load='1i54' size='340' side='right'caption='[[1i54]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1i54]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thunnus_thynnus Thunnus thynnus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I54 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
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{{STRUCTURE_1i54| PDB=1i54 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i54 OCA], [https://pdbe.org/1i54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i54 RCSB], [https://www.ebi.ac.uk/pdbsum/1i54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i54 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYC_THUAA CYC_THUAA] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/1i54_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i54 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The current understanding of electron tunneling through proteins has come from work on systems where donors and acceptors are held at fixed distances and orientations. The factors that control electron flow between proteins are less well understood, owing to uncertainties in the relative orientations and structures of the reactants during the very short time that tunneling occurs. As we report here, the way around such structural ambiguity is to examine oxidation-reduction reactions in protein crystals. Accordingly, we have measured and analyzed the kinetics of electron transfer between native and Zn-substituted tuna cytochrome c (cyt c) molecules in crystals of known structure. Electron transfer rates [(320 s(-1) for *Zn-cyt c --&gt; Fe(III)-cyt c; 2000 s(-1) for Fe(II)-cyt c --&gt; Zn-cyt c(+))] over a Zn-Fe distance of 24.1 A closely match those for intraprotein electron tunneling over similar donor-acceptor separations. Our results indicate that van der Waals interactions and water-mediated hydrogen bonds are effective coupling elements for tunneling across a protein-protein interface.
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===CYTOCHROME C (TUNA) 2FE:1ZN MIXED-METAL PORPHYRINS===
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Electron tunneling in protein crystals.,Tezcan FA, Crane BR, Winkler JR, Gray HB Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5002-6. Epub 2001 Apr 10. PMID:11296248<ref>PMID:11296248</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1i54" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11296248}}, adds the Publication Abstract to the page
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*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11296248 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11296248}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1I54 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thunnus_thynnus Thunnus thynnus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I54 OCA].
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==Reference==
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<ref group="xtra">PMID:11296248</ref><references group="xtra"/>
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[[Category: Thunnus thynnus]]
[[Category: Thunnus thynnus]]
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[[Category: Crane, B R.]]
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[[Category: Crane BR]]
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[[Category: Gray, H B.]]
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[[Category: Gray HB]]
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[[Category: Tezcan, F A.]]
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[[Category: Tezcan FA]]
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[[Category: Winkler, J R.]]
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[[Category: Winkler JR]]
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[[Category: Cytochrome c]]
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[[Category: Mixed-metal]]
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[[Category: Zinc-porphyrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:19:37 2009''
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Current revision

CYTOCHROME C (TUNA) 2FE:1ZN MIXED-METAL PORPHYRINS

PDB ID 1i54

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