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1pso

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{{Seed}}
 
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[[Image:1pso.png|left|200px]]
 
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==The crystal structure of human pepsin and its complex with pepstatin==
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The line below this paragraph, containing "STRUCTURE_1pso", creates the "Structure Box" on the page.
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<StructureSection load='1pso' size='340' side='right'caption='[[1pso]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pso]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptomyces_argenteolus_subsp._toyonakensis Streptomyces argenteolus subsp. toyonakensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
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{{STRUCTURE_1pso| PDB=1pso | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pso OCA], [https://pdbe.org/1pso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pso RCSB], [https://www.ebi.ac.uk/pdbsum/1pso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pso ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PEPA4_HUMAN PEPA4_HUMAN] Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ps/1pso_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pso ConSurf].
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<div style="clear:both"></div>
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===THE CRYSTAL STRUCTURE OF HUMAN PEPSIN AND ITS COMPLEX WITH PEPSTATIN===
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==See Also==
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*[[Pepsin|Pepsin]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_7663352}}, adds the Publication Abstract to the page
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[[Category: Homo sapiens]]
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(as it appears on PubMed at http://www.pubmed.gov), where 7663352 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Streptomyces argenteolus subsp. toyonakensis]]
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{{ABSTRACT_PUBMED_7663352}}
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[[Category: Chernaia MM]]
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[[Category: Fujinaga M]]
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==About this Structure==
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[[Category: James MNG]]
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1PSO is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSO OCA].
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[[Category: Mosimann SC]]
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[[Category: Tarasova N]]
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==Reference==
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<ref group="xtra">PMID:7663352</ref><references group="xtra"/>
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[[Category: Pepsin A]]
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[[Category: Chernaia, M M.]]
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[[Category: Fujinaga, M.]]
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[[Category: James, M N.G.]]
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[[Category: Mosimann, S C.]]
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[[Category: Tarasova, N.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:24:31 2009''
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Current revision

The crystal structure of human pepsin and its complex with pepstatin

PDB ID 1pso

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