2f3g

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{{Seed}}
 
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[[Image:2f3g.png|left|200px]]
 
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==IIAGLC CRYSTAL FORM III==
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The line below this paragraph, containing "STRUCTURE_2f3g", creates the "Structure Box" on the page.
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<StructureSection load='2f3g' size='340' side='right'caption='[[2f3g]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f3g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3g OCA], [https://pdbe.org/2f3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3g RCSB], [https://www.ebi.ac.uk/pdbsum/2f3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3g ProSAT]</span></td></tr>
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{{STRUCTURE_2f3g| PDB=2f3g | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTGA_ECOLI PTGA_ECOLI] The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/2f3g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f3g ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In Escherichia coli, the glucose-specific phosphocarrier protein of the phosphotransferase system (PTS), IIAGlc (IIIGlc in older literature), is also the central regulatory protein of the PTS. Depending upon its state of phosphorylation, IIAGlc binds to a number of different proteins that display no apparent sequence homology. Previous structural studies suggested that nonspecific hydrophobic interactions, specific salt bridges, and an intermolecular Zn(II) binding site contribute to the wide latitude in IIAGlc binding sites. Two new crystal forms of IIAGlc have been solved at high resolution, and the models were compared to those previously studied. The major intermolecular contacts in the crystals differ in detail, but all involve the hydrophobic active site of IIAGlc interacting with a hydrophobic patch on a neighbor and all are shown to be surprisingly similar to the physiologically relevant regulatory interaction of IIAGlc with glycerol kinase. In two crystal forms, a helix on one molecule interacts with the face of another, while in the other crystal form, the primary crystal contact consists of a strand of beta-sheet that contributes to an intermolecular Zn(II) binding site with tetrahedral ligation identical to that of the zinc peptidase thermolysin. Thus, relatively nonspecific hydrophobic interactions combined with specific salt bridges and an intermolecular cation binding site (cation-promoted association) permit a regulatory protein to bind to target proteins that have little or no sequence or structural homology with one another. It is suggested that signal transduction by IIAGlc is a binary switch in which phosphorylation at the active site directly controls binding to target molecules.
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===IIAGLC CRYSTAL FORM III===
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Structural studies of the Escherichia coli signal transducing protein IIAGlc: implications for target recognition.,Feese MD, Comolli L, Meadow ND, Roseman S, Remington SJ Biochemistry. 1997 Dec 23;36(51):16087-96. PMID:9405042<ref>PMID:9405042</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2f3g" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9405042 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9405042}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2F3G is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3G OCA].
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==Reference==
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<ref group="xtra">PMID:9405042</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Comolli, L.]]
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[[Category: Large Structures]]
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[[Category: Feese, M.]]
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[[Category: Comolli L]]
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[[Category: Meadow, N.]]
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[[Category: Feese M]]
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[[Category: Remington, S J.]]
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[[Category: Meadow N]]
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[[Category: Roseman, S.]]
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[[Category: Remington SJ]]
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[[Category: Phosphocarrier]]
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[[Category: Roseman S]]
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[[Category: Phosphotransferase]]
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[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:25:08 2009''
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Current revision

IIAGLC CRYSTAL FORM III

PDB ID 2f3g

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