2gu0

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{{Seed}}
 
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[[Image:2gu0.png|left|200px]]
 
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==Crystal Structure of Human Rotavirus NSP2 (Group C / Bristol Strain)==
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The line below this paragraph, containing "STRUCTURE_2gu0", creates the "Structure Box" on the page.
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<StructureSection load='2gu0' size='340' side='right'caption='[[2gu0]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gu0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_rotavirus_C Human rotavirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GU0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gu0 OCA], [https://pdbe.org/2gu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gu0 RCSB], [https://www.ebi.ac.uk/pdbsum/2gu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gu0 ProSAT]</span></td></tr>
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{{STRUCTURE_2gu0| PDB=2gu0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NSP2_ROTHC NSP2_ROTHC] Involved in genome replication and packaging. Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where replication intermediates are assembled and RNA replication takes place. Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activity activities. The unwiding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures. Unlike typical helicases, NSP2 requires neither a divalent cation nor a nucleotide energy source for helix destabilization. The RTPase activity may account for the absence of the 5'-terminal gamma-phosphate on the minus-strands of dsRNA genome segments (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/2gu0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gu0 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Human Rotavirus NSP2 (Group C / Bristol Strain)===
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==See Also==
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*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16873255}}, adds the Publication Abstract to the page
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[[Category: Human rotavirus C]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16873255 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Jiang X]]
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{{ABSTRACT_PUBMED_16873255}}
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[[Category: Prasad BVV]]
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==About this Structure==
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2GU0 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_rotavirus_(group_c/strain_bristol) Human rotavirus (group c/strain bristol)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GU0 OCA].
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==Reference==
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<ref group="xtra">PMID:16873255</ref><references group="xtra"/>
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[[Category: Jiang, X.]]
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[[Category: Prasad, B V.V.]]
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[[Category: Bristol]]
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[[Category: Hit motif]]
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[[Category: Nsp2]]
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[[Category: Rotavirus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:26:15 2009''
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Current revision

Crystal Structure of Human Rotavirus NSP2 (Group C / Bristol Strain)

PDB ID 2gu0

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