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1tbw

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{{Seed}}
 
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[[Image:1tbw.png|left|200px]]
 
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<!--
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==Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation==
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The line below this paragraph, containing "STRUCTURE_1tbw", creates the "Structure Box" on the page.
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<StructureSection load='1tbw' size='340' side='right'caption='[[1tbw]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tbw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TBW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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{{STRUCTURE_1tbw| PDB=1tbw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbw OCA], [https://pdbe.org/1tbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tbw RCSB], [https://www.ebi.ac.uk/pdbsum/1tbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbw ProSAT]</span></td></tr>
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</table>
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===Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation===
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== Function ==
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[https://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15292259}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15292259 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tb/1tbw_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15292259}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1TBW is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tbw ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:15292259</ref><references group="xtra"/>
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</StructureSection>
[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
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[[Category: Dollins, D E.]]
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[[Category: Large Structures]]
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[[Category: Gewirth, D T.]]
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[[Category: Dollins DE]]
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[[Category: Immormino, R M.]]
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[[Category: Gewirth DT]]
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[[Category: Shaffer, P L.]]
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[[Category: Immormino RM]]
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[[Category: Soldano, K L.]]
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[[Category: Shaffer PL]]
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[[Category: Walker, M A.]]
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[[Category: Soldano KL]]
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[[Category: Amp]]
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[[Category: Walker MA]]
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[[Category: Bergrat]]
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[[Category: Chaperone]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Grp94]]
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[[Category: Hsp90]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:28:18 2009''
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Current revision

Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation

PDB ID 1tbw

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