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1asx

From Proteopedia

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{{Seed}}
 
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[[Image:1asx.png|left|200px]]
 
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==APICAL DOMAIN OF THE CHAPERONIN FROM THERMOPLASMA ACIDOPHILUM==
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The line below this paragraph, containing "STRUCTURE_1asx", creates the "Structure Box" on the page.
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<StructureSection load='1asx' size='340' side='right'caption='[[1asx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1asx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ASX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ASX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1asx| PDB=1asx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1asx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1asx OCA], [https://pdbe.org/1asx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1asx RCSB], [https://www.ebi.ac.uk/pdbsum/1asx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1asx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THSA_THEAC THSA_THEAC] Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/1asx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1asx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the substrate binding domain of the thermosome, the archaeal group II chaperonin, has been determined at 2.3 A resolution. The core resembles the apical domain of GroEL but lacks the hydrophobic residues implied in binding of substrates to group I chaperonins. Rather, a large hydrophobic surface patch is found in a novel helix-turn-helix motif, which is characteristic of all group II chaperonins including the eukaryotic TRiC/CCT complex. Models of the holochaperonin, which are consistent with cryo electron microscopy data, suggest a dual role of this helical protrusion in substrate binding and controlling access to the central cavity independent of a GroES-like cochaperonin.
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===APICAL DOMAIN OF THE CHAPERONIN FROM THERMOPLASMA ACIDOPHILUM===
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Structure of the substrate binding domain of the thermosome, an archaeal group II chaperonin.,Klumpp M, Baumeister W, Essen LO Cell. 1997 Oct 17;91(2):263-70. PMID:9346243<ref>PMID:9346243</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1asx" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_9346243}}, adds the Publication Abstract to the page
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*[[Chaperonin 3D structures|Chaperonin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9346243 is the PubMed ID number.
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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-->
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== References ==
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{{ABSTRACT_PUBMED_9346243}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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1ASX is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ASX OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:9346243</ref><references group="xtra"/>
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[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
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[[Category: Baumeister, W.]]
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[[Category: Baumeister W]]
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[[Category: Essen, L O.]]
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[[Category: Essen L-O]]
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[[Category: Klumpp, M.]]
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[[Category: Klumpp M]]
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[[Category: Atp-binding]]
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[[Category: Chaperonin]]
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[[Category: Groel]]
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[[Category: Hsp60]]
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[[Category: Tcp1]]
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[[Category: Thermoplasma acidophilum]]
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[[Category: Thermosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:34:19 2009''
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Current revision

APICAL DOMAIN OF THE CHAPERONIN FROM THERMOPLASMA ACIDOPHILUM

PDB ID 1asx

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