This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2f29

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:44, 25 October 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2f29.png|left|200px]]
 
-
<!--
+
==Crystal Structure of the Human Sialidase Neu2 Q116E Mutant in Complex with DANA Inhibitor==
-
The line below this paragraph, containing "STRUCTURE_2f29", creates the "Structure Box" on the page.
+
<StructureSection load='2f29' size='340' side='right'caption='[[2f29]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2f29]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F29 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.921&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-
{{STRUCTURE_2f29| PDB=2f29 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f29 OCA], [https://pdbe.org/2f29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f29 RCSB], [https://www.ebi.ac.uk/pdbsum/2f29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f29 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f29_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f29 ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal Structure of the Human Sialidase Neu2 Q116E Mutant in Complex with DANA Inhibitor===
+
==See Also==
-
 
+
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
2F29 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F29 OCA].
+
-
[[Category: Exo-alpha-sialidase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Chavas, L M.G.]]
+
[[Category: Large Structures]]
-
[[Category: Fusi, P.]]
+
[[Category: Chavas LMG]]
-
[[Category: Kato, R.]]
+
[[Category: Fusi P]]
-
[[Category: Monti, E.]]
+
[[Category: Kato R]]
-
[[Category: Tettamanti, G.]]
+
[[Category: Monti E]]
-
[[Category: Tringali, C.]]
+
[[Category: Tettamanti G]]
-
[[Category: Venerando, B.]]
+
[[Category: Tringali C]]
-
[[Category: Wakatsuki, S.]]
+
[[Category: Venerando B]]
-
[[Category: Drug design]]
+
[[Category: Wakatsuki S]]
-
[[Category: Ganglioside]]
+
-
[[Category: Neuraminidase]]
+
-
[[Category: Sialidase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:38:45 2009''
+

Current revision

Crystal Structure of the Human Sialidase Neu2 Q116E Mutant in Complex with DANA Inhibitor

PDB ID 2f29

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f29"
Personal tools